Time: Three hours Note: Do not write anything except roll no. on this question paper
M. Marks: 75
Section-A Multiple Choice Questions- Attempt all questions Q.1 (a) In glycolysis, the conversion of glucose-β-phosphate is effected by the enzyme: 20x1=20 (i) Glucose-6-phosphate (ii) hexokinase (iii) phosphofructokinase (iv) Triosephosphate isomerase (b) ________results from the pancreas’s failure to produce enough insulin: (i) Type 1 diabetes mellitus (ii) Type 2 diabetes mellitus (iv) None of the above (iii) Gestational diabetes (c) Identify the inhibitors of oxidative phosphorylation: (i) oligomycin (ii) Rotenone (iii) Cyanide (iv) All of the above (d) Identify the glycogen storage disease developed due to deficiency of glucose-6-phosphatase (i) Pompe’s disease (ii) Cori’s disease (iii) Von Gierke’s disease (iv) Andersen disease (e) Identify the ketone body: (i) Acetic acid (ii) Acetoacetic acid (iii) Butyric acid (iv) All of the above (f) Hypercholesterolemia is found in (i) Xanthomatosis (ii) Thyrotoxicosis (iii) Hemolytic jaundice (iv) Malabsorption syndrome (g) Melatonin is synthesized in: (i) Hypothalamus (ii) Posterior pituitary gland (iii) Pineal gland (iv) Melanocytes (h) Albinism is due to deficiency of the enzyme: (i) Phenylalanine hydroxylase (ii) Tryosinase (iii) p-Hydroxyphenylpyruvic acid oxidase (iv) Tyrosine dehydrogenase (i) A nucleoside consists of: (i) Nitrogenous base (ii) purine or pyrimidine base + sugar (iii) purine or pyrimidine base + Phosphorus (iv) purine + pyrimidine base +sugar+ Phosphorus (j) The nitrogenous base present in RNA Molecule is (i) Thymine (ii) Hypoxanthine (iii) xanthine (iv) uracil k) Pyrimidine and purine nucleoside biosynthesis share a common precursor: (i) PRPP (ii) Glycine (iii) Fumarate (iv) Alanine (l) Degeneracy of genetic code implies that (i) Codons do not code for specific (ii) Multiple codons must decode the same amino acids (iii) No anticodon on tRNA molecule (iv) Specific codon decodes many amino acids (m) Sucrose is composed of (i) Glucose + glucose (ii) Glucose+Galactose (iii) Fructose + Galactose (iv) Glucose + Fructose (n) Cyclic AMP is chemically: (i) 3’,5’-Cyclic adenosine monophosphate (ii) 2’,5’-Cyclic adenosine monophosphate (iii) 2’,4’-Cyclic adenosine monophosphate (iv) 2’,3’-Cyclic adenosine monophosphate
(o) Following are essential amino acids except: (i) Histidine (ii) Alanine (iii) Methionine (iv) Valine (p) Following are energy rich compound except: (i) Hexosaminidase A and B (ii) Ceramidase (iii) Galactocerebrosidase (iv) Sphingomyelinase (q) Fischer’s ‘lock and ley’ model of the enzyme action implies that: (i) The active site is complementary in shape to that of substance only after intraction (ii) The active site is complementary in shape to that of substance (iii) Substrates change conformation prior to active site interaction (iv) The active site is flexible and adjusts to substrate (r) Neimann-Pick diseases is due to the deficiency of the enzyme: (i) Hexosaminidase A and B (ii) Ceramidase (iii) Galactocerebrosidase (iv) Sphingomyelinase (s) In enzyme kinetics Vmax reflects: (i) The amount of an active enzyme (ii) Substrate concentration (iii) Half the substrate concentratioin (iv) Enzyme substrate complex (t) Identify the coenzyme of Vitamin-B1 (i) Biotin (ii) Pyridoxal phosphate (iii) Thiamine pyrophosphate (iv) FAD Section-B Long answer type questions. Answer any 2 questions. Q.2 Write notes on: (a) Glycolysis (b) Catabolism of Phenyl Alanine Q.3 Write notes on: (a) Organization of mammalian genome. (b) Classification of carbohydrates. Q.4 Discuss in detail about various type of enzyme inhibition with suitable example. Short answer type questions, Answer any 7 questions Q.5 Q.6 Q.7 Q.8 Q.9 Q.10 Q.11 Q.12 Q.13
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Section-C
Write notes on HMP shunt and its significance. Electron transport chain and its mechanism Beta oxidation of saturated fatty acids Write notes on urea cycle. Write notes on structure of DNA. Write notes on energy rich compounds. Discuss the classification and biological role of lipids. Write notes on IUB classification of enzymes. Structure and biochemical function of any three coenzymes.