Program Book

XIV International Congress of Toxicology In conjunction with the

X Mexican Congress of Toxicology October 2-6, 2016

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Program Book Sponsor

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Dear colleagues, students and friends On behalf of the Organizing Committee and the Mexican Society of Toxicology we welcome you to the XIV International Congress of Toxicology to be held this time in conjunction with the X Mexican Congress of Toxicology in the beautiful city of Merida, in the Yucatan Peninsula of Mexico, from October 2-6, 2016. Three years ago we took the responsibility to lead this triennial International Congress that is the most important congress in the discipline, which is organized by the leadership of the International Union of Toxicology. This is the first ICT that is held in a Latin-American country, therefore as a region we wanted to leave the best precedent, therefore we have done our best effort to prepared a Scientific Program of a high level as you will see in the 6 extraordinary plenary lecturers who honor the congress with their participation and in the 55 academic activities with about 180 distinguished speakers from around the world, including 34 symposia, 4 round tables, 2 workshops and 15 oral presentations selected from the abstracts. One of our goals is to offer to all of you a forum to share your day-to-day research data and to discuss the cutting-edge science, besides having the opportunity to establish collaborations and networking with colleagues from different institutions and countries. We also offer you a special supplement in the Toxicology Letters Journal from Elsevier with the abstracts of the congress that will give visibility to your research. We want to take this opportunity to thank to all participants who registered to be part of this congress and to our sponsors that generously contributed to have a successful meeting. Please enjoy the scientific program and meeting people, and we wish you a very pleasant and fun stay in Merida and its surrounding that have a lot to offer to you. Bienvenidos!!

Betzabet Quintanilla-Vega, Ph.D Congress President

Concepción Gutiérrez-Ruiz, Ph.D SoMTox President

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On behalf of the IUTOX Executive Committee and our 63 member societies, I am honored to welcome you to the 14th International Congress of Toxicology (ICTXIV) in the beautiful city of Merida, the first ICT meeting to take place in Latin America. Under the strong leadership of Betzabet Quintanilla–Vega and María Concepción Gutiérrez-Ruiz, the Mexican Society of Toxicology team has worked tirelessly to plan a superb scientific program around the timely theme, “Toxicology and Global Sustainability.” This week we will gather together with our member societies at the General Assembly to report on our activities since 2013 and to undertake the important business of electing new leaders to serve on the Executive Committee and to vote on future ICT and CTDC venues. As I look back over the last three years, I’m grateful to the many IUTOX member society leaders who have welcomed me to their soil and shared their successes, challenges, and extraordinary hospitality. As I pass the gavel to Jun Kanno on October 5, I will do so with gratitude to the Executive Committee, all of whom have worked tirelessly on behalf of IUTOX. I extend a special thanks to each and every Congress participant, speaker, exhibitor, and volunteer for participating in ICTXIV and for making this exceptional week possible. Together, we will share our passion for science among the vibrant culture of this ancient Mayan city marked by the beauty of its buildings, and the sights and sounds of traditional dance and music. Most notable is the graciousness of our Mexican hosts who have provided us with the warmest welcome and hospitality as is the proud tradition in Merida. I thank them for creating an unforgettable Congress experience. Finally, I invite each of you to participate in IUTOX activities and to contribute your time and talents to our work of improving human health through the science and practice of toxicology world-wide. What better way than to get acquainted with our amazing members at the Congress of Toxicology in Developing Countries (CTDC10) in Belgrade, Serbia (April 18-21, 2018) and at the next ICT meeting in Honolulu, Hawaii hosted by the Society of Toxicology (July 15-18, 2019). Adios and Aloha!

Herman Autrup, Ph.D., ATS IUTOX President

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Merit Award

Curtis D. Klaassen, MD., Ph.D

Dr. Klaassen joined the University of Kansas Medical Center in Kansas City, Kansas in 1968 where he spent over 45 years holding numerous positions including University Distinguished Professor as well as Chair of the Department of Pharmacology, Toxicology, and Therapeutics He received his Ph.D. in Pharmacology from the University of Iowa in 1968. Dr. Klaassen’s research interests have centered on how we adapt to chemicals in the environment. Studies have included the regulation of xenobiotic transporters by nuclear receptors, age, and the intestinal microbiome; the mechanism of tolerance to cadmium toxicity by metallothionein; the importance of the transcription factor Nrf2 in protecting against the hepatotoxicity of chemicals; and mechanisms of chemicalinduced thyroid tumors. He has published approximately 525 peer-reviewed articles and more than 80 review articles and chapters for books. Google Scholar indicates that he has an H factor of 101, which indicates that 101 of his publications have been cited more than 101 times. As a leader in toxicology education, Dr. Klaassen has trained over 120 Ph.D. and Postdoctoral students, and so far three have been elected President of SOT and four received the Achievement Award from SOT. He is editor of Casarett and Doull’s Toxicology: The Basic Science of Poisons since 1980, and was author of the toxicology section of Goodman and Gilman’s Pharmacological Basis of Therapeutics from 1980 to 2005. He is Founder (1980) and Course Director of the Mid-America Toxicology Course, an annual postgraduate course to help prepare toxicologists for board examination, and has presented over 450 lectures around the world. Dr. Klaassen has served the toxicology community by being the inaugural Editor-in-Chief of Toxicological Sciences, the new journal of SOT. He was associate editor of the Journal of Pharmacology and Experimental Therapeutics for 24 years and Toxicology and Applied Pharmacology for 10 years. He also served on numerous national and international committees. Dr. Klaassen was elected by his peers to many national and international offices in toxicology, including President of the Society of Toxicology (USA) in 1990-1991, as well as President of the International Union of Toxicology (1992-1995). He was also President of the Seventh International Congress in Toxicology in 1995 held in Seattle, Washington. IUTOX is proud to add the 2016 Merit Award to the long list of awards Dr. Klaassen has been honored with by numerous national and international organizations.

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Deichmann Lecture

Patricia Ostrosky-Wegman, Ph.D

Dr. Ostrosky-Wegman earned her Bachelor degree in Biology from the Faculty of Sciences of the National Autonomous University of Mexico, UNAM. She obtained a Master degree in Human Genetics from the Faculty of Medicine at the University of Tel Aviv, and received a PhD in Pharmacology at the Faculty of Medicine UNAM, graduating with honors. In 1994 Dr. Ostrosky founded the Department of Genomic Medicine and Environmental Toxicology at the Biomedical Research Institute-UNAM, and since 2011 she is the head of this institute, one of the top institutes of Biological Sciences in Mexico. Her research interests include genotoxicity of pesticides, metalloids, and antiparasitic drugs. She was commissioned to the Ministry of Health to serve as General Director of Health Policy Research in 2009. Dr. Ostrosky has been very active in the academic field as President of the Mexican Association of Human Genetics, President of the Latin American Association of Mutagenesis, Carcinogenesis and Environmental Teratogenicity, Secretary of the Latin American Society of Genetics, and member of the Board of the Environmental Mutagen Society. She has been member of the Editorial Board of prestigious Journals such as of Environmental and Molecular Mutagenesis, Mutation Research, Journal of Pharmacological and Toxicological Methods, Environmental Health Perspectives, and Archives of Medical Research. She is member of the National Academy of Medicine and of the Academy for Scientific Research (Mexico). She has created independent strong research groups in the field of toxicogenomics in Mexico, and has mentored and trained more than 100 graduate and undergraduate students, some of them are well recognized researchers at national and international level. She has received several awards highlighting her commitment to mentoring, such as the "Student Educator Award" from the Environmental Mutagen Society in 2005, and the Heberto Castillo Prize in 2007, in the category of Health, Biotechnology and Environment, awarded by the Institute of Science and Technology of Mexico City. Dr. Ostrosky is an example for her tenacity, dedication and passion for science.

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Junior IUTOX Travel Award Alecsandra de Souza, University of Brasilia, Brazil, Abstract #PP9.3 Aleksandra Buha, University of Belgrade-Faculty of Pharmacy, Serbia, Abstract #PP16.30 Alla Tirsina, National Center of Public Health & University of Porto, Portugal, Abstract #PP18.11 Axel Mancebo, National Center for Laboratory Animals Breeding (CENPALAB), Cuba, Abstract #PP13.6 Isabella Bramatti, Hospital University of Western Paraná, Brazil, Abstract #PP11.3 Lam Yim Wan, The University of Hong Kong, China, Abstract #PP11.2 Melissa Schulthess, Universidad Mayor, Chile, Abstract #PP3.6 Shikha Sharma, Jamia Hamdard (Hamdard University), India, Abstract #PP17.11

Senior IUTOX Travel Award Danielle Oliveira, University of São Paulo, Brazil, Abstract #PP18.13 José Belisario Leyva Morales, Universidad de Colima, Mexico, Abstract #PO.23.1 Navasumrit Panida, Chulabhorn Research Institute & Chulabhorn Graduate Institute, Thailand, Abstract #PP8.4 Yana González, National Center for Laboratory Animals Breeding (CENPALAB), Cuba, Abstract #PP13.7

IUTOX Trainee Award - Best posters 1st place- Han-Hsing Tsou, National Yang-Ming University, Taiwan, Abstract #PP12.11 2nd place- Silvia Carolina Moreno Rivas, Centro de Investigación en Alimentación y Desarrollo, Mexico, Abstract #PP16.19 3rd place- Vicente Escamilla Rivera, Cinvestav-IPN, Mexico, Abstract #PP14.4

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Hispanic Organization of Toxicologists (HOT) –Graduate Student Travel Award Carlos Ivan Falcon Rodriguez, Universidad Nacional Autónoma de México (UNAM) & Instituto Nacional de Enfermedades Respiratorias (INER), Mexico, Abstract #PP1.5 Jorge Arturo Soriano Campos, UPAEP, Mexico, Abstract #PP19.8

Trainee Travel Award - IUTOX/SoMTox Andrea Paredes Cortazar Cinthia Aba Guevara Delia Yajaira García Díaz Diana Patricia Rosales Cruz Emmanuel Alejandro Montes Salazar Fanny Azucena Colchero Anateco Gabriela Aguilar López Escalera Gustavo Álvarez Puentos Jorge Abraham Salazar Ramírez José Fernando May Euán José Ignacio Rodríguez Ochoa Karla Karina Rojas Flores Keila Mariana López Arellano Laura López Bañuelos Leticia Rafael Vázquez Magnolia Michele Rodríguez Jaime Martha Patricia López Arellano Mirna Citlali Guerrero Flores Nacira Anahí Albornoz Abud Norma Angélica Pérez Dueñas Paulina Monserrat Pintado de haro Perla Yolanda Reyna Medina viii | P a g e

Roxana Mendoza Toxtle Samantha Merlos de la Rosa Víctor Yáñez Pérez

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XIV International Congress of Toxicology In conjunction with the X Mexican Congress of Toxicology Merida-Mexico, October 2-6, 2016 www.ict-mexico2016.org SoMTox

Event Calendar Sunday (October 02)

8:30 AM – 6:30 PM -Registration 8:30 AM – 5:00 PM -Expo Set Up 8:30 AM – 4:30 PM -CONTINUING EDUCATION COURSES (CE) (For more information, please click on CE courses-Preliminary Program) 5:00 PM – 6:00 PM -OPENING CEREMONY (Uxmal 4 room, Convention Center) 6:00 PM – 7:00 PM -DEICHMANN LECTURE (Uxmal 4 room, Convention Center) Dr. Patricia Ostrosky, Institute of Biomedical Researches, UNAM, Mexico “Genetic Susceptibility and Environmental Triggers in the Development of Disease” Chairperson: Dr. Mariano Cebrián (Cinvestav-Mexico) 7:00 PM – 9:00 PM -WELCOME RECEPTION (Mayan Museum Patio) - Badge required

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Monday (October 03) 8:30 AM – 6:30 PM -Registration 9:00 AM – 5:00 PM 12:30 PM – 2:00 PM -Pesticides Toxicology Network (Red de Toxicología de Plaguicidas) Meeting (Uxmal 7 room) -ALATOX, Members Meeting (Uxmal 6 room)

Tuesday (October 04) 8:30 AM – 6:30 PM -Registration 9:00 AM – 5:00 PM 12.30 PM- 2:00 PM -Global Collaboration Meeting (Uxmal 7 room) -Infant Environmental Health Network (Red de Salud Ambiental Infantil) Meeting (Uxmal 5 room) 5:30 PM – 6:30 PM -SoMToX Members Meeting (Uxmal 7 room)

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Wednesday (October 05)

8:30 AM – 6:30 PM -Registration 9:00 AM – 5:00 PM 12:00 PM – 13:30 PM -IUTOX, Board of Directors Meeting (Fiesta Inn Hotel) 12:30 PM – 2:00 PM -III Reunión de la Red Iberoamericana de Toxicología y Seguridad Química (Uxmal 7 room) 7:00 PM – 11:00 PM -Gala Dinner- La Quinta Montes Molina (http://www.laquintamm.com/index.html) – Ticket required

Thursday (October 06) 12:00 PM – 1:00 PM -Closing ceremony (Uxmal 4 room, Convention Center)

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XIV International Congress of Toxicology In conjunction with the X Mexican Congress of Toxicology

Merida-Mexico, October 2-6, 2016 www.ict-mexico2016.org

SOMTOX

Continuing Education (CE) Courses Sunday (October 2) Date/Time

Topic/Abstract #

ROOM

Sunday 8:30 AM – 4:30 PM

CE 1: Infant Health in Contaminated Sites Chair: Fernando Diaz-Barriga

Uxmal 5

Sunday 8:00 AM – 12:00 AM

CE 2: Understanding Neurodegeneration and Environmental Toxicity Chair: Dr. Rodrigo Franco

Uxmal 7

Sunday 8:00 AM – 4:10 PM

CE 3: Water Security: Integrating Lessons Learned for Water Chair: Elaine Faustman

Uxmal 6

Sunday 8:30 AM – 4:00 PM

CE4: Management of patients presenting acute poisonings Chair: Dra. Olga Martínez Pantaleón

Auditorio “Alonso Fernández”, Cinvestav-Merida

Sunday 12:30 PM – 4:30 PM

Product Safety and Stewardship in the Drug, Food, and Mining, Industries Chair: Dr. Ranulfo Lemus

Uxmal 7

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CE1 Infant Health in Contaminated Sites Sponsored by: Infant Environmental Health Network (Red de Salud Infantil) Chair: Fernando Diaz-Barriga 8:30 am to 4:30 pm 1. Introduction Fernando Diaz-Barriga, Facultad de Medicina, UASPL, SLP, Mexico 2. Contaminated sites in USA Philip Landrigan, Mount Sinai, NY, USA 3. Clinical toxicology and child health Gonzalo García-Vargas, Facultad de Medicina, UJED, Durango, Mexico

CE2 Understanding Neurodegeneration and Environmental Toxicity: Basic Principles and Experimental Approaches Chair: Dr. Rodrigo Franco Time: 8:00 am to 12:00 pm

1. Neurodegeneration: Aging, genetic and environmental risk factors Carmen Frias, Unviersidad Anahuac Mayab, Merida, Mexico 2. Redox Homeostasis, Bioenergetics and Metabolism in the Neurotoxicity of Environmental Exposures Rodrigo Franco, University of Nebraska-Lincoln, Nebraska, USA 3. Experimental approaches to evaluate herbicides neurotoxicity Verónica Rodríguez Córdova, Instituto de Neurobiología-UNAM, Juriquilla, Queretaro, Mexico 4. Design and use of human cell based in vitro tests to evaluate neurotoxic effects of chemicals Marcel Leist, Universitat Konstanz, Germany

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CE3 Water Security: Integrating Lessons Learned for Water Quality and Sustainability Sponsored by: ICSU Chair: Elaine Faustman Time: 8:00 am to 4:10 pm 1. Toxicology and Risk Assessment Principles for Insuring Water Safety. Elaine Faustman, University of Washington, USA 2. Direct and Indirect Effects of Land Use on Water Security Luis Schiesari, University of São Paulo, Brazil 3. Exercising Toxicology to Disclose the Consequences of Water Contaminants: The Case of Manganese Maryse Bouchard, University of Montreal, Canada 4. Arsenic in Water: A South American Case Study Julio Navoni, Federal University of Rio Grande do Norte, Brazil (UFRN) 5. Managing Toxicological Risks in Petrochemical Industries Salmaan Inayat-Hussain, Petronas, Kuala Lumpur, Malaysia 6. Participant case studies * All participants must send an abstract related to his/her research/work area.

CE4 Management of patients presenting acute poisonings Chair: Dra. Olga Martínez Pantaleón Time: 8:30 am to 4:00 pm 1. Main toxidromes Susana Juárez Tobías, CIAT Hospital Central-UASLP, México 2. General management of the poisoned patient Olga Martínez Pantaleón, CIAT, Hospital de Pediatría del CMN Siglo XXI, IMSS, México 3. Pesticides: Organophosphates Evelyn Van Brussel, CIAT, Hospital Central, UASLP, México 4. Natural toxins and envenomations: Snakes bites Evelyn Van Brussel, CIAT, Hospital Central, UASLP, México 5. Natural toxins and envenomations: Arthropods Olga Martínez Pantaleón, CIAT, Hospital de Pediatría del CMN Siglo XXI, IMSS, México xv | P a g e

6. Clinical cases Susana Juárez Tobías, Olga Martínez Pantaleón, Juan Elías Viquez Guerrero, Evelyn Van Brussel

CE5 Product Safety and Stewardship in the Drug, Food, and Mining, Industries Chair: Dr. Ranulfo Lemus Time: 12:30 pm to 4:30 pm

TOPICS: 1. Introduction to Global Product Stewardship Ranulfo Lemus, ATL Inc. – Product Stewardship Services. Cincinnati, OH, USA 2. Safety assessment of additives in the food industry Mari Stavanja, CELANESE Int. Corp; Global Toxicology Leader; Global Product Stewardship Leader, Nutrinova; Irving, TX, USA 3. The Investigational New Drug (IND) and New Drug Application (NDA) Evaluation and Review Process Pedro Del Valle, HOT-SOT, Washington D.C., USA 4. Product Stewardship in the mining industry Ranulfo Lemus, ATL Inc. – Product Stewardship Services. Cincinnati, OH, USA

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XIV International Congress of Toxicology In conjunction with the X Mexican Congress of Toxicology

Merida-Mexico, October 2-6, 2016 www.ict-mexico2016.org SOMTOX

Scientific Program Index

Monday (October 03)

PLATFORM SESSIONS Date/Time

Topic/Abstract #

ROOM

PAGE

Monday 8:30 AM – 9:15 AM

PO1: Air Pollution # PO1.1 – PO1.3

Celestún

13

Monday 8:30 AM – 9:30 AM

PO5: Ecotoxicology # PO5.1 – PO5.4

Uxmal 5

13

Monday 8:30 AM – 9:30 AM

PO6: Educational & Social Aspects in Toxicology # PO6.1 – PO6.4

Uxmal 6

14

Monday 8:30 AM – 9:30 AM

PO7: Endocrine Disruption # PO7.1 – PO7.4

Uxmal 7

14

Monday 8:30 AM – 9:15 AM

PO8: Environmental Epigenetics # PO8.1 – PO8.3

Uxmal 4

15

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PLENARY Date/Time

Topic/Abstract #

ROOM

Monday 9:30 AM – 10:30 AM

Preventing diseases through healthy environments: A global assessment of the environmental burden of diseases” # PL-1

Uxmal 4

PAGE 16

WORKSHOP SESSION Date/Time

Topic/Abstract #

ROOM

Monday 10:30 AM – 12:30 PM

W1: Developmental Toxicology. Different Models, Different endpoints # W1.1 - W1.4

Uxmal 4

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SYMPOSIUM SESSIONS Date/Time

Topic/Abstract #

ROOM

PAGE

Monday 10:30 AM – 12:30 PM

S1: Emerging Issues of Immunotoxicity of Pharmaceuticals # S1.1 – S1.4

Uxmal 5

17

Monday 10:30 AM – 12:30 PM

S2: Effects of Pesticides on Human Health and Ways of Prevention and Control # S2.1 – S2.6

Uxmal 6

17

Monday 10:30 AM – 12:30 PM

S03: Environmental Pollutants, Toxicity and Influence on Human Health # S3.1 – S3.4

Uxmal 7

18

Monday 10:30 AM – 12:30 PM

S04: In Vitro Microphysiological Systems to Predict Toxicity # S4.1 – S4.5

Celestún

19

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POSTER SESSIONS Date/Time

Topic/Abstract #

ROOM

PAGE

Monday 12:30 PM – 2:30 PM

PP1: Air Pollution # PP1.1 – PP1.18

Exhibit Hall

20

Monday 12:30 PM – 2:30 PM

PP2: Alternative Methods/In vitro Testing Methods # PP2.1 – PP2.20

Exhibit Hall

22

Monday 12:30 PM – 2:30 PM

PP3: Analytical Toxicology # PP3.1 – PP3.9

Exhibit Hall

25

Monday 12:30 PM – 2:30 PM

PP4: Carcinogenicity # PP4.1 – PP4.7

Exhibit Hall

27

Monday 12:30 PM – 2:30 PM

PP5: Ecotoxicology # PP5.1 – PP5.26

Exhibit Hall

28

Monday 12:30 PM – 2:30 PM

PP6: Educational & Social Aspects in Toxicology # PP6.1 – PP6.5

Exhibit Hall

32

Monday 12:30 PM – 2:30 PM

PP7: Endocrine Disruption # PP7.1 – PP7.7

Exhibit Hall

33

Monday 12:30 PM – 2:30 PM

PP8: Environmental Epigenetics # PP8.1 – PP8.7

Exhibit Hall

34

Monday 12:30 PM – 2:30 PM

PP9: Environmental Healsierrath # PP9.1 – PP9.28

Exhibit Hall

35

LUNCHEON SEMINARS Date/Time

Topic/Abstract #

ROOM

Monday 12:30 PM – 13:00 PM

LS1: Policy Physicians Committee for Responsible Medicine # LS1

Uxmal 5

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ROUND TABLE Date/Time

Topic/Abstract #

ROOM

Monday 2:30 PM – 4:30 PM

RT1: ToxicOmics Towards New Era: New Uxmal 4 Horizons of Omics Sciences # RT1.1 - RT1.5

PAGE 40

SYMPOSIUM SESSIONS Date/Time

Topic/Abstract #

ROOM

PAGE

Monday 2:30 PM – 4:30 PM

S5: Advances in Mechanisms of Nephrotoxicity # S5.1 – S5.5

Uxmal 5

41

Monday 2:30 PM – 4:30 PM

S6: Innovations in the Human Health Risk Uxmal 6 Assessment of Chemicals # S6.1 – S6.3

42

Monday 2:30 PM – 4:30 PM

S7: Natural Products: Can they be used in Disease Prevention? # S7.1 – S7.4

Uxmal 7

42

Monday 2:30 PM – 4:30 PM

S8: Systematic Reviews in Toxicology # S8.1 – S8.5

Celestún

43

SYMPOSIUM SESSIONS Date/Time

Topic/Abstract #

ROOM

PAGE

Monday 4:30 PM – 6:30 PM

S9: Human Toxicomethylomics: From Global Uxmal 4 DNA Methylation to Gene-specific 5 –Hydroxymethyl-Cytosine # S9.1 – S9.4

43

Monday 4:30 PM – 6:30 PM

S10: The Aryl Hydrocarbon Receptor after Some 25 Years # S10.1 – S10.4

Uxmal 5

44

Monday 4:30 PM – 6:30 PM

S11: Nanomaterial Toxicology, its Uxmal 6 Progress and Reflection to Various Applications, with Special Reference to Carbon-based # S11.1 – S11.4

45

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Monday 4:30 PM – 6:30 PM

S12: Advancing the 3Rs Through Global Harmonization: Case Studies and Future Perspectives # S12.1 – S12.5

Uxmal 7

46

Monday 4:30 PM – 6:30 PM

S13: Mining and Health # S13.1 – S13.4

Celestún

46

Tuesday (October 04) PLATFORM SESSIONS Date/Time

Topic/Abstract #

ROOM

PAGE

Tuesday 8:30 AM – 9:30 AM

PO9: Environmental Health # PO9.1 – PO9.4

Celestún

48

Tuesday 8:30 AM – 9:30 AM

PO12: Human and Clinical Toxicology # PO12.1 – PO12.4

Uxmal 5

49

Tuesday 8:30 AM – 9:30 AM

PO15: Metabolism/Biotransformation/ Polimorphism # PO15.1 – PO15.4

Uxmal 6

50

Tuesday 8:30 AM – 9:30 AM

PO16: Metals # PO16.1 – PO16.4

Uxmal 7

50

Tuesday 8:30 AM – 9:15 AM

PO17: Molecular Toxicology # PO17.1 – PO17.3

Uxmal 4

51

PLENARY Date/Time

Topic/Abstract #

ROOM

Tuesday 9:30 AM – 10:30 AM

“Long Term Impacts of Early Life Exposures” # PL-2

Uxmal 4

PAGE 52

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WORKSHOP SESSION Date/Time

Topic/Abstract #

ROOM

Tuesday 10:30 AM – 12:30 PM

W2: Global Perspectives on Safety, Regulatory and Risk Assessment of Food Additives or Contaminants # W2.1 - W2.5

Uxmal 4

PAGE 53

SYMPOSIUM SESSION Date/Time

Topic/Abstract #

ROOM

PAGE

Tuesday 10:30 AM – 12:30 PM

S14: Environmental Facts on Respiratory Immune Diseases # S14.1 – w4

Uxmal 5

53

Tuesday 10:30 AM – 12:30 PM

S15: Human Toxicity of Pesticides. An inexorable Uxmal 6 burden to mankind? # S15.1 – S15.5

53

Tuesday 10:30 AM – 12:30 PM

S16: Translating Mechanistic Toxicology Discoveries to Public Health Protection # S16.1 – S16.4

Uxmal 7

54

Tuesday 10:30 AM – 12:30 PM

S17: Environmental Endocrine Disrupting Chemicals # S17.1 – S17.5

Celestún

55

Date/Time

Topic/Abstract #

ROOM

Tuesday 12:30 PM – 2:30 PM

PP10: Epidemiological Toxicology # PP10.1 – PP10.13

Exhibit Hall

56

Tuesday 12:30 PM – 2:30 PM

PP11: Food Toxicology # PP11.1 – PP11.15

Exhibit Hall

58

Tuesday 12:30 PM – 2:30 PM

PP12: Human and Clinical Toxicology # PP12.1 – PP12.25

Exhibit Hall

60

Tuesday 12:30 PM – 2:30 PM

PP13: Inmunotoxicity # PP13.1 – PP13.8

Exhibit Hall

63

POSTER SESSIONS PAGE

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Tuesday 12:30 PM – 2:30 PM

PP14: Medicine and Cosmetic Toxicology # PP14.1 – PP14.7

Exhibit Hall

65

Tuesday 12:30 PM – 2:30 PM

PP16: Metals # PP16.1 – PP16.30

Exhibit Hall

66

Tuesday 12:30 PM – 2:30 PM

PP17: Molecular Toxicology # PP17.1 – PP17.20

Exhibit Hall

71

Tuesday 12:30 PM – 2:30 PM

PP18: Mutagenenicity - Genotoxicity # PP18.1 – PP18.18

Exhibit Hall

74

DISTIGUISHED LECTURE Date/Time

Topic/Abstract #

ROOM

Tuesday 2:30 PM – 3:30 PM

"In Vivo Chemical Genotoxin Exposure and DNA Damage in Humans: An overview based on the lymphocyte Cytokinesis Block Micronucleus Assay" # DS-1

Uxmal 4

Date/Time

Topic/Abstract #

ROOM

Tuesday 3:30 PM – 5:30 PM

RT2: Maternal Exposure to Nanoparticles – How Uxmal 4 does it affect the Fetus? Status, Mechanisms, and Future Directions # RT2.1 - RT2.4

PAGE 76

ROUND TABLE PAGE 77

SYMPOSIUM SESSION Date/Time

Topic/Abstract #

ROOM

PAGE

Tuesday 3:30 PM – 5:30 PM

S18: Chromosomal Instability # S18.1 – S18.4

Uxmal 5

77

Tuesday 3:30 PM – 5:30 PM

S19: Paternal Exposures, Sperm Health and Reproductive Success # S19.1 – S19.4

Uxmal 6

78

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Tuesday 3:30 PM – 5:30 PM

S20: Toxicology data information networks in the Uxmal 7 21st century # S20.1 – S20.5

79

Tuesday 3:30 PM – 5:30 PM

S21: Timely Protection of Public Health Celestún from Environmental Exposure to Neurotoxicants in Latin America: Current Challenges, and Strategies to Overcome them # S21.1 – S21.4

79

Wednesday (October 05)

PLATFORM SESSIONS Date/Time

Topic/Abstract #

ROOM

PAGE

Wednesday 8:30 AM – 9:30 AM

PO19: Nanotoxicology # PO19.1 – PO19.4

Celestún

80

Wednesday 8:30 AM – 9:30 AM

PO22: Occupational Toxicology # PO22.1 – PO22.3

Uxmal 4

81

Wednesday 8:30 AM – 9:30 AM

PO23: Pesticides # PO23.1 – PO23.4

Uxmal 5

81

Wednesday 8:30 AM – 9:30 AM

PO25: Reproduction and Development # PO25.1 – PO25.4

Uxmal 6

82

Wednesday 8:30 AM – 9:30 AM

PO26: Target Organ Toxicity # PO26.1 – PO26.4

Uxmal 7

83

PLENARY Date/Time

Topic/Abstract #

ROOM

Wednesday 9:30 AM – 10:30 AM

"Children’s Health and the Environment: A Global Uxmal 4 Perspective" # PL-3

PAGE 84

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WORKSHOP SESSION Date/Time

Topic/Abstract #

ROOM

PAGE

Wednesday 10:30 AM – 12:30 PM

W3: Food Safety and Environmental Toxicology # W3.1 to W3.4

Uxmal 4

84

SYMPOSIUM SESSION Date/Time

Topic/Abstract #

ROOM

PAGE

Wednesday 10:30 AM – 12:30 PM

S22: Adverse Effects of Pesticide Exposure on Fetus and Newborn Infant # S22.1 – S22.5

Uxmal 5

85

Wednesday 10:30 AM – 12:30 PM

S23: Listening to the Microbiome: What is says about Environmental Chemicals, Drugs, Disease and Toxicology # S23.1 – S23.5

Uxmal 6

86

Wednesday 10:30 AM – 12:30 PM

S24: Organ-on-chip Technology: Challenges and Interpretation of the data # S24.1 – S24.5

Uxmal 7

86

Wednesday 10:30 AM – 12:30 PM

S25: Toxicity of the New psychoactive Substances – an Epidemiological, Mechanistic and Clinical Overview # S25.1 – S25.5

Celestún

87

Date/Time

Topic/Abstract #

ROOM

Wednesday 12:30 PM – 2:30 PM

P 19: Nanotoxicology # PP19.1 – PP19.15

Exhibit Hall

88

Wednesday 12:30 PM – 2:30 PM

PP20: Natural Products # PP20.1 – PP20.17

Exhibit Hall

90

Wednesday 12:30 PM – 2:30 PM

PP21: Neurotoxicology # PP21.1 – PP21.26

Exhibit Hall

93

Wednesday 12:30 PM – 2:30 PM

PP22: Occupational Toxicology # PP22.1 – PP22.13

Exhibit Hall

97

POSTER SESSION PAGE

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Date/Time

Topic/Abstract #

ROOM

PAGE

Wednesday 12:30 PM – 2:30 PM

PP23: Pesticides # PP23.1 – PP23.28

Exhibit Hall

99

Wednesday 12:30 PM – 2:30 PM

PP24: Regulatory Toxicology and Risk Assessment # PP24.1 – PP24.10

Exhibit Hall

103

Wednesday 12:30 PM – 2:30 PM

PP25: Reproduction and Development # PP25.1 – PP25.17

Exhibit Hall

105

Wednesday 12:30 PM – 2:30 PM

PP26: Target Organ Toxicity # PP26.1 – PP26.19

Exhibit Hall

107

LUNCHEON SEMINARS Date/Time

Topic/Abstract #

ROOM

Wednesday 12:30 PM – 2:00 PM

LS2: Mentoring Forum # LS2

Uxmal 5

PAGE 110

DISTIGUISHED LECTURE Date/Time

Topic/Abstract #

ROOM

Wednesday 2:30 PM – 3:30 PM

"Gatekeeper and watchman for Toxicology – The Uxmal 4 Role of the Microbiome in Toxicology" # DS-2

PAGE 111

SYMPOSIUM SESSION Date/Time

Topic/Abstract #

ROOM

PAGE

Wednesday 3:30 AM – 5:30 PM

S26: Scientific Tool for Environmental Studies in Vulnerable Populations: ECOHEALTH # S26.1 – S26.4

Uxmal 5

111

Wednesday 3:30 AM – 5:30 PM

S27: Understanding Multipollutant Air Mixtures Health Effects # S27.1 – S27.4

Uxmal 6

111

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Date/Time

Topic/Abstract #

ROOM

Wednesday 3:30 AM – 5:30 PM

S28: Environmental Exposures and Neurotoxicity: Molecular Mechanisms, Epidemiology and Risk Assessment # S28.1 – S28.5

Uxmal 7

112

Wednesday 3:30 AM – 5:30 PM

S29: Occupational Toxicology and Chemical Risk Celestún Assessment # S29.1 – S29.4

113

Wednesday 3:30 AM – 5:30 PM

S30: Innovations in Environmental Epigenetics: Tales from Endocrine Disruptor to Cancer # S30.1 – S30.5

114

Uxmal 4

PAGE

Thursday (October 06)

PLENARY Date/Time

Topic/Abstract #

ROOM

Thursday 9:00 AM – 10:00 AM

"Development of an integrated and comprehensive Uxmal 4 toxicity testing system: future direction of toxicology research in China" # PL-4

PAGE 115

WORKSHOP SESSION Date/Time

Topic/Abstract #

ROOM

Thursday 10:00 AM – 12:00 PM

W4: Genomic Biomarkers in Risk Assessment # W4.1 to W4.4

Uxmal 4

PAGE 115

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SYMPOSIUM SESSION Date/Time

Topic/Abstract #

ROOM

PAGE

Thursday 10:00 AM – 12:00 PM

S31: Adulterants and Contaminants in Herbal Products, and Ethnic Remedies: New Warnings and Strategies for Surveillance # S31.1 – S31.5

Uxmal 5

116

Thursday 10:00 AM – 12:00 PM

S32: Environmental Causes of Breast Cancer # S32.1 – S32.4

Uxmal 6

116

Thursday 10:00 AM – 12:00 PM

S33: IUPHAR: Influence of Ethnicity, Genetics and Age on Drug Response and Toxicity # S33.1 – S33.4

Uxmal 7

117

Thursday 10:00 AM – 12:00 PM

S34: Application of the Adverse Outcome Pathway (AOP) Concept to Evaluate a Link between Pesticides and Parkinson’s Disease # S34.1 – S34.4

Celestún

118

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Monday, October 03 8:30 AM – 9:30 AM Celestún room

Scientific Program

PLATFORM SESSION PO1: Air Pollution Chairpersons: Patricia Segura (Mexico), and Michael Kleinman (USA)

#PO1.1

8:30 AM

Analysis of microRNAs in lung cells exposed to particulate matter (PM10). Quezada-Maldonado EM1, García-Cuellar CM1*, Vaca-Paniagua F1, 2, Sánchez-

Pérez Y1, Chirino YI2. 1Subdirección de Investigación Básica. Instituto Nacional de Cancerología, Ciudad de México, México, 2Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, UNAM, Estado de México, México

#PO1.2

8:45 AM

Chemical exposure and cost of health effects; the case of tobacco smoking. Albores A. Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, Ciudad de México, México

#PO1.3

9:00 AM

An animal model to evaluate the toxic effects of coal dust. CaballeroGallardo K, Olivero-Verbel J. Environmental and Computational Chemistry Group. School of Pharmaceutical Sciences, University of Cartagena, Cartagena, Colombia

Monday, October 03 8:30 AM – 9:30 AM Uxmal 5 room PLATFORM SESSION PO5: Ecotoxicology Chairpersons: Miguel Betancourt (Mexico), and Jesús Olivero (Colombia)

#PO5.1

8:30 AM

Acute copper effect on antioxidant system response of the freshwater pond snail (Lymnaea stagnalis) tissues. Atli G1, Grosell M2. 1Vocational

School of Imamoglu, Cukurova University, Adana, Turkey, 2RSMAS, University of Miami, Miami, FL 33145, USA

#PO5.2

8:45 AM

Relevant, sensitive, non-standard sublethal tests as aquatic ecotoxicity biomarkers. Gooneratne SR1, Drewes C2, Wellby M1.1Faculty of Agriculture and Life Sciences, Lincoln University, Canterbury, New Zealand, 2Department of Zoology and Genetics, Iowa State University, Ames, Iowa, USA

#PO5.3

9:00 AM

Metals and metallothioneins in Morelet’s crocodile (Crocodylus moreletii) from Rio Hondo. Buenfil-Rojas AM1, Alvarez-Legorreta T1, CedeñoVazquez JR2.1Environmental Biotechnology, Department of Sustainability Sciences, El Colegio de la Frontera Sur, Chetumal, Quintana Roo, Mexico, 2Systematic, Ecology and Management of Aquatic Resources, Department of Aquatic Systematic and Ecology, El Colegio de la Frontera Sur, Chetumal, Quintana Roo, México

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#PO5.4

9:15 AM

Removal of organochlorine pesticides (OCs) using constructed wetlands in a northwestern Mexican agricultural valley. GarciaHernandez J1, Aguilera-Marquez D1, Sofia-Cital F3, Leyva-Garcia G1, RamirezHernandez J3, Glenn EP2. 1Centro de Investigación en Alimentación y Desarrollo, A.C. (CIAD)-Coordinación Guaymas, Guaymas, Sonora México, 2Universidad Autónoma de Baja California, Instituto de Ingeniería, 3University of Arizona, Soil, Water and Environmental Science Department (SWES)

Monday, October 03 8:30 AM – 9:30 AM Uxmal 6 room PLATFORM SESSION PO6: Educational & Social Aspects in Toxicology: Chairwoman: Elena Hernández-Ramón (HOT-SOT, USA)

#PO6.1

8:30 AM

The European TOX-OER project: Learning toxicology through open educational resources. Vicente-Vicente L, Prieto M, Pescador M, Casanova AG, Hernández-Sánchez MT, Morales AI. Toxicology Unit, University of Salamanca, Spain, Group of Translational Research on Renal and Cardiovascular Diseases (TRECARD). Salamanca, Spain, IBSAL, Spain

#PO6.2

8:45 AM

Development of a medical Toxicology Curriculum in Spanish with content informed by a population survey for medical trainees in the Dominican Republic. Kairus R1, Santos C2,3, Kazzi Z4, Bentley S5, Olmedo R6. 1Pontificia

Universidad Católica Madre y Maestra, Santiago, Dominican Republic, University School of Medicine, Centers for Disease Control, Atlanta, GA, USA, 3Icahn School of Medicine at Mount Sinai, New York, NY, USA, 4Emory University School of Medicine, Atlanta, GA, USA, 5Mount Sinai School of Medicine, New York, NY, USA, 6Mount Sinai School of Medicine, New York, NY, USA 2Emory

#PO6.3

9:00 AM

North American Society promotes advances in in vitro and in silico Toxicology. Sullivan KS1 and Hill E2. 1Physicians Committee for Responsible Medicine, Washington, DC, USA; 2Institute for In Vitro Sciences, Gaithersburg, MD, USA

#PO6.4

9:15 AM

State Center advisory in toxicology and pharmacology experience in Boyacá, Colombia. Rodríguez Cortés N, Sierra de Mayorga CC. Boyacá Health Department, CITOXBOY Tunja, Colombia

Monday, October 03 8:30 AM – 9:30 AM Uxmal 7 room PLATFORM SESSION PO7: Endocrine Disruption : Chairperson: Miroslav Styblo (USA), and Adolfo Sierra-Santoyo (Mexico) 14 | P a g e

#PO7.1

8:30 AM

Perfluorooctane sulfonate (PFOS) can alter gonadotropins secretion by modifying glutamate concentration and N-methyl-Daspartate receptors (NMDAr) in the pituitary gland. Lafuente A, Salgado R, López-Doval S. University of Vigo, Laboratory of Toxicology, School of Sciences, Orense, Spain

#PO7.2

8:45 AM

Adequacy of current test methods to identify adverse effects caused by endocrine disruptors. Manibusan MK1, Touart LW2, Freeman E1. 1Center

for Chemical Regulation and Food Safety, Exponent Health and Environmental, Washington, DC, USA, 2Equiparent Consulting, Woodbridge, Virginia, USA

#PO7.3

9:00 AM

Alterations in the menstrual cycle of teenagers not occupationally exposed to a mixture of pesticides in an agricultural area of San Luis Potosi, Mexico. Rodríguez-López AG1, Mejía-Saucedo RL1, CalderónHernández J2, Llamazares-Azuara L3, Yáñez-Estrada LG1. 1Facultad de Medicina, Laboratorio de Género, Salud y Ambiente, 2Coordinación para la Innovación y la Aplicación de la Ciencia y a Tecnología, 3Facultad de Medicina, Laboratorio Renal, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México

#PO7.4

9:15 AM

Perinatal exposure of rat pups to the HexaBromoCycloDoDecane (HBCDD) α-isomer affects sexual maturation and copulatory behavior at the adult stage. Olivier B, Zalka L, Olry JC, Jondreville C, Bouillaud-Kremarik P, Schroeder H. URAFPA, INRA UC340, Université de Lorraine, Vandoeuvre-lès-Nancy, France

Monday, October 03 8:30 AM – 9:15 AM Uxmal 4 room PLATFORM SESSION PO8: Environmental Epigenetics Chairpersons: Octavio Jiménez (Mexico), and Kenneth Ramos (USA)

#PO8.1

8:30 AM

MicroRNA-126 is dysregulated in endothelial cells exposed to silver nanoparticles. González-Palomo AK1, 2, Jiménez-Avalos JA1, 2, Saldaña-Villanueva K, Pérez-Vázquez FJ2,3, Yacamán MJ3, Pérez-Maldonado IN1,2. 1Laboratorio de Toxicología Molecular, Coordinación para la Innovación y Aplicación de la Ciencia y Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí (UASLP), 2Facultad de Medicina, Universidad Autónoma de San Luis Potosí, 3Department of Physics & Astronomy, The University of Texas at San Antonio (UTSA), San Antonio, Texas, USA

#PO8.2

8.45 AM

Multigenerational effects of chronic low-dose natural uranium contamination: epigenetic inheritance of methylation signature. Elmhiri G, Gloaguen C, Kereselidze D, Grison S, Legendre A, Elie C, Tack K, Benderitter M and Souidi M. Institut de Radioprotection et de Sûreté Nucléaire, Direction de la Radioprotection de l’Homme, Service de RadioBiologie et d’Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale, Fontenay-aux Roses Cedex, France

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#PO8.3

9:00 AM

DNA methylation changes in Mexican children exposed to arsenic from two historical mining areas in San Luis Potosí. Alegría-Torres JA1, 2, Carrizales-Yánez L3, Díaz-Barriga F3, Rosso-Camacho F2, Mota V4, Tarantini L4, Bollati V4. 1Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato. México, 2Laboratorio de Investigación Molecular en Nutrición (LIMON), Universidad del Centro de México UCEM, San Luis Potosí, México, 3Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, México, 4Department of Clinical Sciences and Community Health, Center of Molecular and Genetic Epidemiology, University of Milan, Italy

Monday, October 03 9:30 AM – 10:30 AM Uxmal 4 room PLENARY #PL-1 Preventing disease through healthy environments: A global assessment of the environmental burden of disease. Neira M and Prüss-Ustün A. Department of Public Health, Environmental and Social Determinants of Health, World Health Organization, Geneva, Switzerland

Chairperson: Peter Goering (FDA, USA)

Monday, October 03 10:30 AM – 12:30 AM Uxmal 4 room

WORKSHOP SESSION

W1: Developmental Toxicology. Different Models, Different endpoints Chairpersons: Maria F. Cavieres (Chile) and Wilma De Grava Kempinas (Brazil)

#W1.1

10:30 AM

In vitro and in vivo models to study teratogenicity. Misoprostol as an example. Cavieres MF. Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Valparaíso, Chile

#W1.2

10:55 AM

Developmental origins of reproductive disorders in the adult: the example of glucocorticoids and statins. Kempinas WG. Department of Morphology, Institute of Biosciences of Botucatu, UNESP – Univ Estadual Paulista, Botucatu, SP, Brazil

#W1.3

11:20 AM

Computer simulation of developmental processes and toxicities. Knudsen TB. National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA

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#W1.4

11:45 AM

Nanomaterials toxicity and teratogenicity in aquatic environment using Rhinella arenarum model. Yslas EI. Department of Molecular Biology, Universidad Nacional de Río Cuarto, CONICET, Río Cuarto, Argentina

12:10 PM

Panel Discussion

Monday, October 03 10:30 AM – 12:30 PM Uxmal 5 room SYMPOSIUM SESSIONS S1: Emerging Issues of Immunotoxicity of Pharmaceuticals Chairpersons: Kazuichi Nakamura (Japan), and Kenneth L. Hasting (USA)

#S1.1

Interspecies comparison of placental structure and function with attention to transfer of immunoglobulins and biopharmaceuticals. DeSesso JM. Exponent, Center for Toxicology and Mechanistic Biology, Alexandria, VA, United States and Georgetown University School of Medicine, Department of Biochemistry and Molecular & Cellular Biology, Washington, DC, United States

#S1.2

Immunotoxicological reactions induced by adjuvanted vaccines. Nakamura K. Kitasato University, Laboratory of Toxicology, School of Veterinary Medicine, Japan

#S1.3

TLRs and evaluation of adverse innate immune responses. Burleson GR. Burleson Research Technologies, Inc. (BRT), 120 First Flight Lane, Morrisville, North Carolina, United States

#S1.4

Development of novel nano-carrier with safety for vaccine against infectious diseases. Yoshioka Y. Vaccine Creation Project, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

Monday, October 03 10:30 AM – 12:30 PM Uxmal 6 room SYMPOSIUM SESSIONS S2: Effects of Pesticides on Human Health and Ways of Prevention and Control Chairpersons: Chairperson: Jesús A. Marín (Nicaragua)

#S2.1

Effects of pesticides on human health and ways of prevention and control: "custody". Calle-Uribe P. NorthLAN Stewardship Manager for Crop Protection, Department of Toxicology, LAN, Bogota, Bogota, Colombia

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Poisonings by pesticides in Guatemala. Guzmán-Quilo MC. Department of

#S2.2

Toxicology, Centro de Información y Asesoría Toxicológica. Escuela de Química Farmacéutica. Facultad de Ciencias Químicas y Farmacia. Universidad de San Carlos de Guatemala. Guatemala

#S2.3

Pesticide exposure in Chile: ten years report from the Catholic University Poison Information Center. Ríos JC1,2, Mieres JJ1, Medel P1, Solari S2, Cerda P1, Silva L1, Olivares P1, Paris E1. 1Centro de Información Toxicológica, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Department of Clinical Laboratory, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago Chile

#S2.4

Paraquat poisoning, Therapeutic Guide. Berroteran-Mejia J, LozanoChavarria LM, Marin JA. Department of Toxicology, CIVATOX, Nicaragua

#S2.5

Study on prevention and health guidelines pesticide accidents in the Canton Montalvo, Province of River, Ecuador. Gaibor-Carpio J. Department of Toxicology, Institution CIATOX. Quayaquil, Quito, Ecuador

#S2.6

Effects of pesticides on human health and ways of prevention and control. Marin JA. Department of Toxicology, CIVATOX, Minister of Health, Managua, Managua, Nicaragua

Monday, October 03 10:30 AM – 12:30 PM Uxmal 7 room SYMPOSIUM SESSIONS S3: Environmental Pollutants, Toxicity and Influence on Human Health Chairpersons: Arturo Ortega (Mexico) and Michael Aschner (USA)

#S3.1

Manganese-induced neurotoxicity: lessons from worms to human neonates. Aschner M. Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Blvd, Bronx, NY 10461, USA

#S3.2

Effects of low-level lead exposure on blood pressure in a population-based study in Southern Brazil. Almeida Lopes ACB1, Silbergeld EK2, Navas-Acien A2, Zamoiski R3, Martins Jr AC4, Camargo AEI5, Urbano MR1,6, Mesas AE1,7, Paoliello MMB1. 1Graduate Program in Public Health, State University of Londrina - UEL, Londrina, Paraná, Brazil, 2Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA, 3Radiation Epidemiology Branch of the Division of Cancer Epidemiology and Genetics. National Cancer Institute, National Institutes of Health, Washington D.C., USA, 4Graduate Program in Toxicology, Faculty of Pharmaceutical Sciences of University of São Paulo – USP, Ribeirão Preto, São Paulo, Brazil, 5Graduate Program in Health Sciences, Center of Health Sciences, State University of Londrina - UEL, Londrina, Paraná, Brazil, 6Department of Statistics, State University of Londrina - UEL, Londrina, Paraná, Brazil, 7Department of Public Health, State University of Londrina – UEL, Londrina, Paraná, Brazil

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#S3.3

Health risk assessment for air pollutants: lung inflammation and extra pulmonary adverse events are correlated to particulate matter size, origin and season of collection. Palestini P. Department of Medicine and Surgery, POLARIS Centre, University of Milano-Bicocca, Monza, Italy

#S3.4

Particulate matter disrupts the glutamate uptake in cerebellar glia cells: Implications for glutamatergic transmission. Suárez-Pozos E, De Vizcaya-Ruiz A, Ortega A. Departamento de Toxicología, Cinvestav, Ciudad de México, México

Monday, October 03 10:30 AM – 12:30 PM Celestún room SYMPOSIUM SESSIONS S4: In Vitro Microphysiological Systems to Predict Toxicity Partially sponsored by: Center for Alternatives to Animal Testing Chairpersons: Helena Hogbert (USA), and David Pamies (USA)

#S4.1

Chip based microphysiological systems – a step toward emulation of systemic aspects of human biology in vitro. Horland R1, Maschmeyer I1, Dehne M1, Hasenberg T1, Ramme A1, Lorenz A1, Jaenicke A1, Hübner J2, Schimek K2, Atac-Wagegg B1, Lauster R2, Marx U1. 1TissUse GmbH, Berlin, Germany, 2Department of Medical Biotechnology, Technische Universität Berlin, Berlin, Germany

#S4.2

iPSC derived brain microphysiological system for developmental neurotoxicity. Pamies D1, Barreras P2,3, Block K1, Makri G2,4, Kumar A2,3, Wiersma D1, Smirnova L1, Zang C2,4, Bressler J5, Christian KM2,4, Harris G1, Berlinicke CJ7, Kyro K8, Song H2,4,6, Pardo CA2, Hartung T1,9, Hogberg HT1. 1Center for Alternatives to Animal Testing, 2Department of Neurology, 3Division of Neuroimmunology, 4Institute for Cell Engineering, 5Hugo Moser Institute at the Kennedy Krieger 6The Solomon Snyder Department of Neuroscience, 7Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21205, USA, 8US Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD 21010 USA, 9University of Konstanz, Germany

#S4.3

Ex-vivo female reproductive tract integration in a 3D microphysiologic system. Burdette J1, Coppeta J2, Isenberg B2, Borenstein JT2, Xiao S3, Zhu J3, Rashedi A3, Kim J3, Olalekan S3, Getsios S4,, McKinnon K3, Pavone ME3,, Malpani S3; Sefton EC3, Woodruff TK3. 1Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60607, 2The Charles Stark Draper Laboratory, Cambridge, MA, 2Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago IL, 60611, 4Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago IL, 60611

#S4.4

High-throughput microfluidic platform for culture of 3D kidney tissue models. Lanz HL, Vormann M, van den Heuvel A, Ng CP, van Vught R, Trietsch SJT, Joore J, Vulto P. MIMETAS BV, J.H. Oortweg 19, NL-2333CH Leiden, The Netherlands

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#S4.5

Human

organs-on-chips. Bahinski A. GlaxoSmithKline, King of Prussia, PA, United States

Safety

Pharmacology,

Monday, October 03 12:30 PM – 2:30 PM Exhibit Hall POSTER SESSION PP1: Air Pollution Displayed: 9:30 AM – 4:30 PM Author Attended: 13.00 PM – 2:30 PM #PP1.1

Wood combustion: higher IL-8 release in THP-1 cells exposed to beech logwoods UFP (< 100 nm) compared to conifer UFP. Corsini E1, Papale A1, Galbiati V1, Fermo P2, Vecchi R3, Ozgen S4, Galli CL1. 1Laboratory of Toxicology, DiSFeB, 2Dipartimento di Chimica, 3Dipartimento di Fisica, Università degli Studi di Milano, Milan, Italy, 4DICA, Politecnico di Milano, Milan, Italy

#PP1.2

Levels and toxicological effects of heavy and trace metals in cigarette sidestream smoke particulates. Li LA, Cheng LC, Chung WC, Liu HJ. National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan, Republic of China

#PP1.3

Experimental exposure to ozone induces activation and translocation of NFkB and is reverted by curcumin. Nery-Flores SD, Ramírez-Vázquez JJ, Mendoza-Magaña ML, Ramírez-Herrera MA, CortezÁlvarez CR, Romero-Prado M. Laboratorio de Neurofisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México

#PP1.4

An in vitro model of dry eye on conjunctival cells combining exposure to low humidity, airflow, and formaldehyde gas. Vitoux MA1, Achard S2, Kessal K1, Melik Parsadaniantz S1, Baudouin C1,3, BrignoleBaudouin F1,3. 1Vision Institute, UMR S 968 INSERM, UMR 7210 CNRS, UPMC, Paris, France, 2EA 4064, Faculté de Pharmacie, Université Paris-Descartes, Sorbonne Paris Cité, Paris, France, 3Quinze-Vingts National Ophtalmology Hospital, Paris, France

#PP1.5

Inhalation of concentrated PM2.5 affects pulmonary CYP450 activity in a guinea pig model of asthma. Falcon-Rodriguez CI1,2, Garcia-Alonso LI2,3, Hernández-Ojeda SL4, Espinosa-Aguirre JJ4, De VizcayaRuiz A5, Rosas-Perez I6, Segura-Medina P2. 1Posgrado en Ciencias Biológicas, UNAM. 2Departamento de Investigación en Hiperreactividad Bronquial, INER. 3Facultad de Ciencias, UNAM. 4Departamento de Toxicología y Medicina Genómica, Instituto de Investigaciones Biomédicas, UNAM. 5Departamento de Toxicología, CINVESTAV-IPN. 6Centro de Ciencias de la Atmósfera, UNAM. Mexico City, Mexico

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#PP1.6

Assessment of aldosterone synthase (CYP11B2), mineralocorticoid receptor expression and markers of fetal cardiac gene reprogramming in rats exposed to fine particles. Morales-Rubio R, Uribe-Ramirez M, Aztatzi-Aguilar O, De Vizcaya-Ruiz A. Department of Toxicology, CINVESTAV, Mexico City, Mexico

#PP1.7

Effect of exposure to low doses of ozone on signaling endoplasmic reticulum and the generation of beta-amyloid 1-42 intraneuronal in rat hippocampus. Rodríguez-Martínez E, BorgonioPérez G, and Rivas-Arancibia S. Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México

#PP1.8

PM10 chemical characteristics at the Universidad Libre Bogotá. Rodríguez A, Martínez L, Catacoli R. Department of Environmental Engineering, Institution Universidad Libre, Bogotá D.C., Colombia

#PP1.9

Seasonal variations of DNA adducts in mothers and newborns exposed to polycyclic aromatic hydrocarbons in Mexico City. Maciel-Ruiz JA1, López-Rivera C1, Robles R2, Veloz-Martínez MG2, Petrosyan P1, Gonsebatt, ME1. 1Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, México, 2Hospital de Gineco-Obstetricia 3 “Dr. Víctor Manuel Espinosa de los Reyes Sánchez”, Centro Médico Nacional “La Raza”, México

#PP1.10

Association of chemical components and endotoxin in PM2.5 with early kidney damage. Aztatzi-Aguilar OG1, Rojas-Lima E2, Barbier O1, De Vizcaya-Ruiz A1.1Department of Toxicology, CINVESTAV-IPN, Mexico City, Mexico, 2Faculty of Health Sciences, UATx, Tlaxcala City, Tlaxcala, Mexico

#PP1.11

Mass median diameter of particulate matter of Comarca Lagunera, Mexico. Diaz-May MA1, Campos-Trujillo A2, Herrera-Peraza E2, Goytia-Acevedo R3, Chan-Keb CA1, Ake-Canche B1, Perez-Balan RA1. 1Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Campeche, Campeche, México, 2Departamento de Medio Ambiente y Energía, Centro de Investigación en Materiales Avanzados, Chihuahua México, 3Departamento de Investigación, Facultad de Medicina Gómez Palacio, Universidad Juárez del Estado de Durango, Durango, México

#PP1.12

Atmospheric agro-industrial sugarcane emissions: it´s effect on health and properties of the habitants. Guerrero-Carrera LM1, Soto-Estrada A1, Landeros-Sánchez C1, Vargas-Mendoza MC1, Carrillo-Ávila AE2. 1Programa en Agroecosistemas Tropicales, Colegio de Postgraduados, Campus Veracruz. Tepetates, Veracruz, Veracruz, México, 2Programa en Agricultura Tropical, Colegio de Postgraduados, Campus Campeche, Sihochac, Champotón, Campeche, México

#PP1.13

Immunologic response to ozone and PM