JORDI LLOP ROIG ACADEMICAL DEGREE PhD in Inorganic Chemistry (2002) Universitat Ramon Llull Chemical Engineering (1997) Institut Químic de Sarrià Graduate in Chemistry (1996) Universitat Ramon Llull

PROFESSIONAL EXPERIENCE October 2007 – Now Company

CIC biomaGUNE (San Sebastián, Guipúzcoa, Spain)

Position

Group Leader – Radiochemistry - Head of Radiochemistry Department Radioprotection Officer Scientific Advisor of CIC biomaGUNE

Duties

Lead and supervise all R&D projects related to the production and/or development of radiotracers and the application in Nuclear Imaging Techniques. Design and production of new radiotracers labelled with PET and SPECT isotopes. Education of students (PhDs, post docs) and lead own research projects. Lead projects related to the Molecular Imaging Unit. Facility design and start up.

June 2003 – August 2007 Company

Institut Alta Tecnologia PRBB – Fundació Privada (Barcelona, Spain)

Position

Production Responsible of Radiopharmaceutical Laboratory

Duties

Responsible of Radiochemistry Department – PET Laboratory Facility design and start up Production of PET Radiotracers labelled with

11

C,

18

F,

13

N and

15

O,

including [11C]methionine, [11C]choline, [11C]raclopride, [11C]PK11195,

[11C]acetate, [11C]flumazenil, [11C]-NNC112, [11C]-PIB, [11C]harmine, [18F]FDG, [18F]FMISO, [18F]FEAU, [18F]F-, [13N]ammonia, [15O]water. Production of SPECT Radiotracers labeled with [

123

I]IBZM, [

123

I]CNS-1261, [

123

123

I, including

I]R91150.

Qualification of the equipment and validation of manufacturing processes for all the above-mentioned radiotracers. Lead and supervise all R&D projects related to the production and/or development of radiotracers. Design and Execution of Clinical and Pre-clinical studies in collaboration with several Pharmaceutical Companies: GlaxoSmithKline, Esteve, Sanofi-Aventis, Advancell. Design and Execution of Equipment-related projects in collaboration with companies: IBA, Bioscan.

September 2004 – August 2007 Company

Universitat Pompeu Fabra (Barcelona, Spain)

Position

Associate Professor

Duties

Teacher of the Subject: “Advanced Imaging Techniques”, corresponding to 4th level of University degree “Human Biology”.

September 2002 – June 2003 Company

Uppsala University PET Center – Uppsala Research Imaging Solutions (Uppsala, Sweden)

Position

Post-Doc Researcher

Duties

Research on [11C]CO labelling strategies.

February 2002 – September 2002 Company

PET Center – Clínica Universitaria de Navarra (Pamplona, Spain)

Position

Post-Doc Researcher

Duties

Research on 13N labelling strategies Production of PET Radiotracers labeled with 11C, 18F and 13N, including [11C]methionine, 13

[ N]ammonia.

[11C]raclopride,

[18F]FDG,

[18F]FDOPA,

and

January 1998 – February 2002 Facility

Institut de Ciència de Materials de Barcelona (ICMAB-CSIC)

Position

PhD student

Duties

Research on boron chemistry, focusing in the development of new mixed Cobalt sandwich compounds.

September 1996 – December 1997 Facility

Institut Químic de Sarrià – Universitat Ramon Llull (Barcelona, Spain)

Position

Final Degree Project

Duties

Development of new corrosion inhibitors focused to prevent corrosion in Nuclear Power Plants.

September 1996 – December 1997 Facility

Institut Químic de Sarrià – Universitat Ramon Llull (Barcelona, Spain)

Position

Half time contract (combined with Final Degree Project)

Duties

Lead removing from metallic pieces. Cleaning strategies. Water analysis and quality control of commercial reagents.

TEACHING EXPERIENCE September 2004 – August 2007 Company

Universitat Pompeu Fabra (Barcelona, Spain)

Subject

Human Biology 4th level / Advanced Imaging Techniques

Duration

30 hours / year

July 2001 Company

Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona, Spain)

Subject

Chemistry for Teachers

Duration

30 hours

July 2000 Company

Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona, Spain)

Subject

Chemistry for Teachers

Duration

30 hours

July 1999 Company

Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona, Spain)

Subject

Chemistry for Teachers

Duration

30 hours

February 1999 – May 1999 Company

Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona, Spain)

Subject

Laboratory – Industrial Samples Analysis – 5th level

Duration

300 hours

October 1998 – February 1999 Company

Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona, Spain)

Subject

Laboratory – Inorganic Chemistry – 2nd level

Duration

200 hours

October 1997 – May 1998 Company

Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona, Spain)

Subject

Laboratory – Inorganic Chemistry – 2nd level

Duration

400 hours

October 1996 – May 1997 Company

Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona, Spain)

Subject

Laboratory – Inorganic Chemistry – 2nd level

Duration

400 hours

DIRECTION OF PhD’s Student

Larraitz Gil

Project

PhD

Title

Synthesis of

68

Ga-labelled nanoparticles and evaluation of their

suitability as contrast agents for the early diagnose of pancreatic cancer. Lecture date December 2014

Student

Kiran Babu Gona

Project

PhD

Title

Synthesis of

11

C-labelled drug analogs by using [11C]CO and cross

coupling palladium mediated carbonylation reactions. Lecture date December 2014

Student

Carlos Pérez

Project

PhD

Title

Synthesis of nanoparticles labeled with positron emitters: determination of their pharmacokinetic properties.

Lecture date September 2013

Student

Vijay Gaja

Project

PhD

Title

Synthesis of PET tracers with application in BNCT.

Lecture date September 2013

Student

Naiara Vázquez

Project

PhD

Title

Development of new D2 receptor ligands analogs labelled with Carbon11 and incorporating a 1,2-dicarba-closo-dodecaborane moiety in its structure.

Lecture date May 2012

Student

Vanessa Gómez-Vallejo

Project

PhD

Title

Development of New Strategies for the Synthesis of Radiotracers Labelled with Short-Lived Isotopes: Application to 11C and 13N.

Lecture date July 2010

DIRECTION OF FINAL DEGREE PROJECTS Student

Anna Berini

Project

Final Degree Project

Title

Síntesis y evaluación in vivo del radiotrazador [18F]FEAU

Lecture date February 2011

Student

Patricia López

Project

Final Degree Project

Title

Validación del módulo de síntesis Synthera para la manufactura del radiotrazador 2-[18F]fluoro-2-desoxi-D-glucosa en condiciones de alta actividad

Lecture date April 2008

Student

Marta Bosque

Project

Final Degree Project

Title

Síntesis de radiotrazadores marcados con

13

N con aplicación en el

diagnóstico de patologías isquémicas Lecture date October 2007

Student

Alex Corella Frasnedo

Project

Final Degree Project

Title

Desenvolupament i validació de la producció de radiotraçadors PET marcats amb 11C utilitzant com agent metilant triflat de [11C]-metil

Lecture date August 2007

Student

Vanessa Gómez -Vallejo

Project

Final Degree Project

Title

Síntesis y validación de trazadores marcados radiactivamente con 11

C. Aplicación en el diagnóstico por imagen

Lecture date December 2005

123

Iy

SCIENTIFIC PUBLICATIONS JOURNAL PAPERS 2012 •

Pérez-Campaña, C; Gómez-Vallejo, V; Martín, A; San Sebastian, E; Moya, S.E; Reese, T; Ziolo, R.F; Llop, J; Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation. Analyst, 2012. In press. DOI: 10.1039/C2AN35863H.

•

Gaja, V; Gómez-Vallejo, V; Cuadrado, M; Borrell, J.I; Llop, J; Synthesis of 13Nlabelled radiotracers using microfluidic technology. Journal of Labelled Compounds

and

Radiopharmaceuticals,

2012.

55:

332-338.

DOI:

10.1002/jlcr.2946. •

Gómez-Vallejo, V; Martín, A; Aginagalde, M; San Sebastian, E; Padro, D; Cossio, F.P; Llop, J; Biodistribution and metabolism of 11C-labeled Kendine 91 in mice and rats. Applied Radiation and Isotopes, 2012. 70: 2545-2551. DOI: 10.16/j.apradiso.2012.05.020.

•

Aginagalde, M; Gómez-Vallejo, V; Vara, Y; Cossio, F. P; Llop, J; Synthesis of 11

C-labeled kendine-91, a histone deacetylase inhibitor. Applied Radiation and

Isotopes, 2012. 70: 2552-2557. DOI: 10.1016/j.apradiso.2012.05.016. •

Vázquez, N; Gómez-Vallejo, V; Llop, J; Synthesis of novel pyrazole derivatives incorporating one dicarba-closo-dodecaborane unit. Tetrahedron Letters, 2012. 53: 4743-4746. DOI: 10.1016/j.tetlet.2012.06.113.

•

Martin, A; San Sebastián, E; Gómez-Vallejo, V; Llop, J; Positron emission tomograghy with [13N]ammonia evidences long-term cerebral hyperperfusion after 2h-transient focal ischemia. Neuroscience, 2012. 213: 47-53. DOI: 10.1016/j.neuroscience.2012.0.3.050.

2011 •

Gómez-Vallejo, V; Llop, J; Fully automated and reproducible radiosynthesis of high specific activity [11C]raclopride and [11C]Pittsburg compound-B using the combination of two commercial synthesizers. Nuclear and Medicine Communications,

2011.

32

(11):

1011-1017.

DOI:

10.1097/MNM.0B013E32834B45A3. •

Catafau, A.M; Bullich, S; Nucci, G; et al; Contribution of SPECT measurements of D2 and 5-HT2A occupancy to the clinical development of the antipsychotic

SB-773812. Journal of Nuclear Medicine, 2011. 52(4): 526-534. DOI: 10.2967/jnumed.110.081885. •

Rojas, S; Martín, A; Pareto, D; Herance, J.R; Abad, S; Ruiz, A; Flotats, N; Gispert, J.D; Llop, J; Gómez-Vallejo, V; Planas, A.M; PET with 11C-Flumazenil in the rat shows preservation of binding sites during the acute phase after 2htransient

focal

ischemia.

Neuroscience,

2011.

182:

208-216.

DOI:

10.1016/j.neuroscience.2011.03.013. •

Vázquez, N; Gómez-Vallejo, V; Calvo, J; Padro, D; Llop, J; Synthesis of D2 receptor ligands analogs incorporating one dicarba-closo-dodecaborane unit. Tetrahedron Letters, 2011. 52: 615-618. DOI: 10.1016/j.tetlet.2010.11.161.

2010 •

Figueiras, F.P; Jiménez, X; Pareto, D; Gómez, V; Llop, J; Herance, R; Rojas, S; Gispert, J.D; Simultaneous Dual-tracer PET imaging of the rat brain and its application in the study of cerebral ischemia. Molecular Imaging and Biology, 2010. 13(3): 500-510. DOI: 10.1007/s11307-010-0370-5.

•

Gómez-Vallejo, V; Borrell, J.I; Llop, J; A convenient synthesis of

13

N-labelled

azo compounds: a new route for the preparation of amyloid imaging PET probes. European Journal of Medicinal Chemistry, 2010. 45: 5318-5323. DOI: 10.1016/j.ejmech.2010.08.053. •

Gómez-Vallejo, V; Kato, K; Oliden, I; Calvo, J; Baz, Z; Borrell, J.I; Llop, J; Fully automated synthesis of

13

N-nitrosothiols. Tetrahedron Letters, 2010. 51:

2990-2993. DOI:10.1016/j.tetlet.2010.03.122. 2009 •

Catafau, A.M; Suarez, M; Bullich, S; Llop, J; et al; Within-subject comparison of striatal D2 receptor occupancy measurements using [123I]IBZM SPECT and [11C]Raclopride

PET.

NeuroImage,

2009.

46:

447-458.

DOI:

10.1016/j.neuroimage.2009.02.005. •

Martín, A; Rojas, S; Pareto, D; Santalucia, T; Millán, O; Abasolo, I; Gómez, V; Llop, J; Gispert, J.D; Falcon, C; Bargalló, N; Planas, A.M; Depressed glucose consumption at reperfusion following brain ischemia does not correlate with mitochondrial dysfunction and development of infarction: an in vivo positron emission tomography study. Current Neurovascular Research, 2009; 6(2): 8288.

•

Gómez-Vallejo, V; Kato, K; Hanyu, H; Minegishi, K; Borrell, J.I; Llop, J; Efficient system for the preparation of [13N]Labeled Nitrosamines. Bioorganic and

medicinal

chemistry

Letters,

2009.

19:

1913-1915.

DOI:

10.1016/j.bmcl.2009.02.066. •

Gómez-Vallejo, V; Llop, J; Specific activity of [11C]CH3I synthesized by the “wet” method: main sources of non-radioactive carbon. Applied Radiation and Isotopes, 2009. 67: 111-114. DOI: 10.1016/j.apradiso.2008.09.012.

•

Llop, J; Gómez-Vallejo, V; Bosque, M; Quincoces, G; Peñuelas, I; Synthesis of S-[13N]Nitrosoglutathione (13N-GSNO) as a new potential PET imaging agent. Applied

Radiation

and

Isotopes,

2009.

67:

95-99.

DOI:

10.1016/j.apradiso.2008.09.014. 2008 •

Gómez, V; Amador, V; Gispert, J.D; Llop, J; New Method for Routine Production of L-[Methyl]methionine: In Loop Synthesis. Journal Labelled Compounds

and

Radiopharmaceuticals,

2008.

51(1):

83-86.

DOI:

10.1002/jlcr.1483. 2007 •

Segura, J; Fillat, C; Andreu, D; Llop, J; Millan, O; de la Torre, B.G; Nikolovski, Z; Gómez, V; Andreu, N; Pinyot, A; Gispert, J.D; Pascual, J.A; Monitoring Gene Therapy by External Imaging mRNA: Pilot Study on Murine Erytropoietin. Therapeutic Drug Monitoring, 2007. 29(5): 612-618.

•

Rojas, S; Martín, A; Arranz, M.J; Pareto, D; Purroy, J; Verdaguer, E; Llop, J; Gómez, V; Gispert, J.D; Millan, O; Chamorro, A; Planas, A; Imaging Brain Inflammation with [11C]PK11195 by PET and Induction of the Peripheral-Type Benzodiazepine Receptor after Transient Focal Ischemia in Rats. Journal of Cerebral Blood Flow and Metabolism, 2007. 27(12): 1975- 1986. DOI: 10.1038/sj.jcbfm.9600500.

2006 •

Catafau, AM; Danus, M; Bullich, S; Nucci, G; Llop, J; Abanades, S; Cunningham, VJ; Eersels, JL; Pavia, J; Farre, M; Characterization of the SPECT 5-HT2A Receptor Ligand

123

I-R91150 in Healthy Volunteers: part 2-Ketanserin

Displacement. Journal of Nuclear Medicine, 2006. 47(6): 929-937. •

Catafau, AM; Danus, M; Bullich, S; Llop, J; Perich, J; Cunningham, VJ; Plaza, P; Penengo, MM; Eersels, JL; Squassante, L; Ros, D; Barbanoj, M;

Characterization of the SPECT 5-HT2A Receptor Ligand 123I-R91150 in Healthy Volunteers: part 1- Pseudo-equilibrium Interval and Quantification Methods. Journal of Nuclear Medicine. 2006. 47(6): 919-928. 2005 •

Catafau, AM; Perez, V; Penengo, MM; Bullich, S; Danús, M; Puigdemont, D; Pascual, JC; Corripio, I; Llop, J; Perich, J; Álvarez, E; SPECT of Serotonin Transporters Using

123

I-ADAM: Optimal Imaging Time After Bolus Injection

and Long-Term Test-Retest in Healthy Volunteers. Journal of Nuclear Medicine. 2005; 46: 1301-1309. •

Viñas, C; Llop, J; Teixidor, F; Kivekäs, R; Sillanpää, R; Restricted Rotation in Unbridged Derivatives.

Rotational Chem.

Behaviour Eur.

J.

of

closo-[Co(η5-NC4H4)(C2B9H11)] 2005;

11:1933-1941.

DOI:

10.1002/chem.200400445. 2004 •

Rahman, O; Llop, J, Langström, B; Oragnic Bases as Additives to Improve the radiochemical Yields of [11C]Ketones Prepared by the Suzuki Coupling Reaction. Eur. J. Org. Chem. 2004; 2674-2678. DOI: 10.1002/ejoc.200400038.

2003 •

Llop, J; Masalles, C; Teixidor, F; Viñas, C; Sillanpää, R; Kivekäs, R; The [3,3Co(1,2-C2B9H11)2]- Anion as Platform for New Materials: Synthesis of its Functionalized Monosubstituted Derivatives Incorporating Synthons for Conducting Organic Polymers. J. Chem. Soc. Dalton Trans. 2003; 556-561. DOI: 10.1039/b211860m.

2002 •

Llop, J; Viñas, C; Teixidor, F; Victori, L; Coordinating Properties of Mixed Pyrrolyl/Dicarbollyde Cobalt Metallocene-type Complexes. J. Chem. Soc., Dalton Trans. 2002; 8:1559-1565. DOI: 10.1039/b110918a.

•

Llop, J; Viñas, C; Oliva, JM; Teixidor, F; Flores, MA; Kivekäs, R; Sillanpää, R; Modulation of the C-C Distance in Disubstituted 1,2-R2-o-Carboranes. Crystal Structure of closo-1,2-(SPh)2-1,2-C2B10H10. Journal of Organometallic Chemistry. 2002; 657(1-2): 232-238.

•

Llop, J; Viñas, C; Teixidor, F; Kivekäs, R; Sillanpää, R; Frozen-Out Rotamers of Mixed Cobaltacarborane Complexes. Organometallics. 2002; 21(2):355-361. DOI: 10.1021/om010711l.

•

Llop, J; Viñas, C; Teixidor, F; Victori, L; Kivekäs, R; Sillanpää, R; Redox Potential Modulation in Mixed Sandwich Pyrrolyl/Dicarbollide Complexes. Inorganic Chemistry. 2002; 41(13): 3347-3352. DOI: 10.1021/ic011285z.

•

Masalles, C; Llop, J; Viñas, C; Teixidor, F; Extraordinary Overoxidation Resistance Increase in Self-Doped Polypyrroles by Using Non-Conventional Low Charge-Density Anions. Advanced Materials. 2002; 14(11): 826-829.

2001 •

Llop, J; Viñas, C; Teixidor, F; Victori, L; Kivekäs, R; Sillanpää, R; C-C Plasticity in Boron Chemistry: Modulation of the Cc…Cc Distance in Mixed Pyrrolyl/Dicarbollide Complexes. Organometallics. 2001; 20:4024-4030. DOI: 10.1021/om010511.

•

Sillanpää, R; Llop, J; Viñas, C; Teixidor, F; Kivekäs, R; n5-(3)-1-methyl-1,2dicarbollyl-n5-2’,5’-dimethylpyrrolylcobalt(III). Acta crystallographica. 2001; C57:900-901.

BOOK CHAPTERS •

Gómez-Vallejo, V.; Vijay, G.; Zoziorowski, J.; Llop, J; Specific activity of 11Clabelled radiotracers: a big challenge for PET chemists. Positron Emission Tomography: Current Clinical and Research Aspects, 2012. Cap. 7, 183-208.

•

Llop, J; Teixidor, F; Viñas, C; Kivekäs, R; Sillanpää, R; Pyrrole and ocarborane. Contemporary Boron Chemistry. Ed. R.S.C. 2000; 308-315.

PATENTS •

Rahman, O; Langström, B; Kihlberg, T; Llop, J; Methods for Carbon Isotope Labeling Synthesis of Ketones and Amines by Suzuki Coupling Reactions Using Carbon-Isotope

Monoxide.

Registry

Number:

Application

Number

PCT/IB2004/004199. International Publication Number: WO 05/066100 A1. Priority Date: December, 24th 2003. Owner: GE Healthcare Limited. Priority Countries: US. Other Countries: US.

ADDITIONAL FORMATION 2012 •

Curso de Revisión y Actualización de las Normas de Protección Radiológica Accredited by: ACPRO

•

Curso de Revisión y Actualización de GMPs. Accredited by: IBA Molypharma

•

Curso Manipulación y Experimentación animal. Categoría B. Accredited by: Animalaria

2011 •

I Jornadas de NeuroImagen y VIII Jornadas del Grupo PET Accredited by: Semnim

•

19th International Symposium on Radiopharmaceutical Sciences Accredited by: Society of Radiopharmaceutical Sciences

2010 •

IV Jornadas de Formación Teórico-Práctica en MRI/MRS: Aplicación en animales de laboratorio Accredited by: UAB

2009 •

IBA Users Meeting Accredited by: IBA

•

18th International Symposium on Radiopharmaceutical Sciences Accredited by: Society of Radiopharmaceutical Sciences

•

IBA Hands on – Cyclotron Training Accredited by: IBA

2008 •

XIII Imeboron – International Conference on Boron Chemistry Accredited by: CSIC

•

World Molecular Imaging Congress 2008 Accredited by: Academy of Molecular Imaging

•

XI TurkuPET Symposium Accredited by: University of Turku

•

14th European Symposium on Radiopharmacy and Radiopharmaceuticals Accredited by: European Association of Nuclear Medicine

2007 •

Workshop en Imagen Molecular Accredited by: Consejería de Sanidad de la Comunidad de Madrid

2006 •

Training in risk prevention and emergency plan Accredited by: CYCLOPS, Servicio de Prevención

•

cGMPs aplicada a Radiofármacos Accredited by: SVS (Sociedad de Validación de Sistemas)

2004 •

Changes Control and Re-validation Accredited by: SVS (Sociedad de Validación de Sistemas)

•

Training program consisted on Hands-on sessions pertaining to the operation and Maintenance of the Cyclone 18/9TM cyclotron Accredited by: IBA (Ion Beam Applications)

2003 •

Radioactive Facility Supervisor in Nuclear Medicine Area Accredited by: INTE (Institut de Tècniques Energètiques de la Unversidad Politécnica de Cataluña)

•

Termochemical Risks Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

•

Reometry and Reology Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

•

Advanced Surface Characterization Techniques Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

•

X-Ray Diffraction – Single Crystal Structure Analysis Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

2002 •

Radio-element and their use: Radiochemistry Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

•

Advanced Quantum Chemistry Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

SCIENTIFIC MEETINGS CONTRIBUTIONS 2012 •

Gago, B; Marin, C; Garcia-Garcia, D; Gómez-Vallejo, V; Llop, J; RodriguezOroz, M; Quetiapine effects on apomorphine-induced abnormal involuntary movements in unilateral 6-hydroxydopamine-lesionedrats. Poster. Neuroscience 2012. New Orleans, USA. October, 2012.

•

Martín, A; Gómez-Vallejo, V; San Sebastián, E; Padró, D; Makuerkiaga, I; Llop, J; PET Imaging of metabolism, perfusión and dopamine receptor after stroke. Poster. 2012 World Molecular Imaging Conference. Dublin, Ireland. September, 2012.

•

Martín, A; Moraga, A; San Sebastián, E; Szczupak B; Gómez-Vallejo, V; Makuerkiaga, I; Padró, D; Llop, J; Lizasoaín, I; Role of Toll-like receptor-4 in neuroinflammation using positron emission tomography after cerebral ischemia. Poster. 2012 World Molecular Imaging Conference. Dublin, Ireland. September, 2012.

•

Martín, A; San Sebastián; E; Gómez-Vallejo, V; Llop, J; Positron Emission Tomography with [13N]Ammonia evidences long-term cerebral hyperfusion after 2h-transient focal ischemia. Poster. 2012 World Molecular Imaging Conference. Dublin, Ireland. September, 2012.

•

Sansaloni, F; Lagares, J.I; Arce, P; Llop, J; Characterization of the proton beam from an IBA cyclone 18/9 with radiochromic film EBT. Poster. 14th International Workshop on Targetry and Target Chemistry. Cancun, Mexico. August, 2012.

•

Pérez-Campaña, C; Puigivila Viñeta M; Gómez Vallejo, V; Llop, J; Synthesis, characterization and biodistribution of metal oxide nanoparticles by means of Positron Emission Tomography (PET). Poster. 9th World Biomaterials Congress. Chengdu, China. June, 2012.

•

González Esparza, M; Gómez-Vallejo, V; Llop, J; Síntesis, purificación y control de calidad de [11C]PE2I y [18F]altanserina para su utilización en un estudio preclínico. Poster. 32º Congreso de la Sociedad Española de Medicina Nuclear e Imagen Molecular (SEMNIM). Cádiz, Spain. June, 2012.

•

Pérez-Campaña, C; Puigivila Viñeta M; Gómez Vallejo, V; Llop, J; Síntesis, caracterización y biodistribución de nanopartículas de óxidos metálicos mediante Tomografía por Emisión de Positrones. Poster. 32º Congreso de la

Sociedad Española de Medicina Nuclear e Imagen Molecular (SEMNIM). Cádiz, Spain. June, 2012. •

Gómez-Vallejo, V; Gaja, V; Llop, J; Síntesis de azoderivados marcados con nitrógeno-13 mediante microfluidos: evaluación como marcadores de placa βamiloide. Oral Communication. 32º Congreso de la Sociedad Española de Medicina Nuclear e Imagen Molecular (SEMNIM). Cádiz, Spain. June, 2012.

•

Puigivila, M; Vázquez, N; Gómez-Vallejo, V; Llop, J; Síntesis de 1-(N-(1[metil-11C]-2-metilen-pirrolidin)-formamida)-1,7-dicarba-closo-dodecaborano: Evaluación como ligando de receptores dopaminérgicos D2. Poster. 32º Congreso de la Sociedad Española de Medicina Nuclear e Imagen Molecular (SEMNIM). Cádiz, Spain. June, 2012.

•

Gaja, V; Gómez-Vallejo, V; Llop, J; Synthesis of 13N-labelled radiotracers using microfluidic technology. Oral Communication. 16th European Symposium on

Radiopharmacy and Radiopharmaceuticals (ESRR). Nantes, France. April, 2012. 2011 •

Yordanov, A; Shulman, S; Gómez-Vallejo, V: Llop, J; Is there future for comercial C-11 PET drug manufacturing using disposable kits?; Poster. 19th International Symposium on Radiopharmaceutical Sciences (ISRS). Amsterdam, Netherlands. August, 2011.

•

Llop, J; Synthesis of radiolabelled nanoparticles for biodistribution studies in animal models; Oral communication Safety issues of nanomaterials along their life cycle. Barcelona, Spain. May, 2011.

•

Gómez-Ros, J.M; Romero, A; Belogni, R; Esposito, A; Moraleda, M; Lagares, J.I; Sansaloni, F; Arce; P; Llop, J; Verificación experimental de un nuevo espectrómetro de neutrones para dosimetría ambiental y de área; Poster. II Congreso Conjunto SEFM-SEPR. Seville, Spain. May, 2011.

•

Llop, J; Pérez Campaña, C; Gómez-Vallejo, V; San Sebastián, E; Martín, A; Reese, T; Ziolo, F.R; Moya, S.E; Synthesis of positron emitter labeled metal oxide nanoparticles for biodistribution studies by direct activation with high energy protons; Oral Communication. ImagineNano. Bilbao, Spain. April, 2011.

•

Pérez Campaña, C; Gómez-Vallejo, V; Ziolo, F.R; Reese, T; Moya, S.E; Llop, J; Synthesis, characterization and activation of metal oxide nanoparticles; Poster. ImagineNano. Bilbao, Spain. April, 2011.

2010 •

Gómez-Vallejo, V; Borrell, J.I; Llop, J; A convenient synthesis of 13N-labelled azo compounds: a new route for the preparation of amyloid PET probes; Oral Communication. International Workshop on Biomedical Applications for microPET. Seville, Spain. September, 2010.

2009 •

Gómez-Vallejo, V; Kato, K; Hanyu, M; Minegishi, K; Borrell, J.I; Llop, J; Efficient method to synthesize [13N]-Nitrosamines; Poster. 18th International Symposium on Radiopharmaceutical Sciences. Edmonton, Canadá. July, 2009.

2008 •

Catafau, AM; Suarez, M; Bullich, S; Gunn, R; Rabiner, E; Llop, J; Laruelle, M; Within-subject Comparison of Striatal D2 Receptor Occupancy Measurements using

123

I-IBZM SPECT and

11

C-Raclopride PET; Oral Communication. SNM

Annual Meeting. New Orleans, LA (USA). 2008. •

Catafau, AM; Bullich, S; Suarez, M; Cot, A; Gunn, R; Gallego, J; Pavia, J; Llop, J; Rabiner, E; Ros, D; Laruelle, M; Striatal Dopamine D2 Receptor Occupancy Measurements using [123I]IBZM SPECT and [11C]Raclopride PET: A WithinSubject

Comparison

Study;

Oral

Communication.

7th

International

Symposium on Functional Neuroreceptor Mapping of the Living Brain. Pittsburg (USA). July, 2008. 2007 •

Gómez, V; Millán, O; Llop, J; Gispert, J.D; Andreu, N; Pinyot, A, Nikolovsky, Z; de la Torre, B.G; Pascual, J.A; Andreu, D; Fillat, C; Segura, J; Isotope-based imaging of erythropoietin mRNA; Poster. AMI Annual Conference. Rhode Island, USA. September, 2007.

•

Gómez, V; Cebrán, P; Doutres, A; Gispert, J.D; Amador, V; Llop, J; Nuevo método para la producción rutinaria de

11

C-Metionina mediante captura y

reacción en loop; Oral Communication. XXVIII Congreso de la Sociedad Española de Medicina Nuclear. León, Spain. June, 2007.

•

Llop, J; Cebrián, P; Doutres, A; Gómez, V; Búsqueda de las fuentes de CO2 no radiactivo en la manufactura de radiotrazadores marcados con carbón-11; Poster. XXVIII congreso de la Sociedad española de Medicina Nuclear. León, Spain. June, 2007.

2006 •

Gispert, J.D; Pareto, D; Llop, J; Gómez, V; Rojas, S, Martín, A; Planas, A.M; Millán, O; Simultaneous dual-isotope PET imaging; Poster. AMI Annual Conference. Florida, USA. September, 2006.

•

Llop, J; Rodríguez, S; Brosa, C; Gómez, V; Puesta a punto de la síntesis, purificación y formulación de

18

F-Fluoromisonidazol (18F-FMISO); Oral

Communication. XXVII Congreso de la Sociedad Española de Medicina Nuclear. Granada, Spain. June, 2006. •

Corella, A; Gómez, V; Brosa, C; Llop, J; Comparativa del marcaje de Racloprida utilizando como agente metilante

11

C-CH3I y

11

11

C-

C-CH3OTf; Poster.

XXVII Congreso de la Sociedad Española de Medicina Nuclear. Granda, Spain. June, 2006. •

Gispert, J.D; Pareto, D; Llop, J; Gómez, V; Rojas, S; Martín, A; Planas, A.M; Millán, O; Imagen PET simultánea de dos radiotrazadores; Poster. XXVII Congreso de la Sociedad Española de Medicina Nuclear. Granada, Spain. June, 2006.

•

Gómez, V; Borrell, J.I; Rojas, S; Martín, A; Planas, A.M; Gispert, J.D; Millán, O; Llop, J; Síntesi i validació d’un radiotraçador per a receptors benzodiazepínics perifèrics:

11

C-PK11195; Oral Communication. Quarta

Trobada de Joves Investigadors dels Països Catalans. Lleida, Spain. January, 2006. 2005 •

Gómez, V; Llop, J; Gispert, J.D; Martínez, M; Martín, A; Rojas, S; García, S; Planas, A; Dierssen, M; Sanfeliu, C; Millán, O; PET technology for the study of CNS: First steps at IAT-PRBB; Poster. 4th Annual Meeting Mouse Models of Neuroscience Research. Barcelona, Spain. December, 2005.

•

Gómez, V; Doutres, A; Miralles, E; Llop, J; Puesta a punto del método de síntesis, purificación, acondicionado y control de calidad de radiotrazadores PET marcados con carbono-11; Oral Communication. XXVI Congreso de la Sociedad Española de Medicina Nuclear. Gran Canaria, Spain. June, 2005.

2004 •

Llop, J; Aspectos Generales de la Radioquímica con Emisores de Positrones; Oral Communication. PET-Tomografía por Emisión de Positrones: Aplicaciones en Investigación Clínica. Barcelona, Spain. 2004.

2000 •

Llop, J; Teixidor, F; Viñas, C; Kivekäs, R; Sillanpää, R; Pirrol y o-carborano. Poster. IX Reunión Científica Plenaria de Química Inorgánica-QIES2000. Bilbao, Spain. September, 2000.

1998 •

Masalles, C; Tutusaus, O; Llop, J; Teixidor, F; Viñas, C; Borrós, S; Elaboration de Nouvelles Membranes Capteuses de Cations à Partir du Polypyrrole Dopé Avec des Composés Sándwich du Cobaltacarborane. Poster. 8me Tournée Chimie Grand Sud-Ouest. Pau, France. 1998.

RESEARCH PROJECTS PUBLIC FOUNDATION PROJECT TITLE RADIOMI: Innovative radiochemistry to advance molecular imaging FUNDING

European Union

FROM

2013 TO

MAIN RESEARCHER

2016 Jordi Llop (PI subproject)

PROJECT TITLE Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment FUNDING

European Union (FP7-NMP-2012-LARGE-6)

FROM

2013 TO

MAIN RESEARCHER

2016 Kai Savolainen

PROJECT TITLE Estudio del papel de los receptores dopaminérgicos y los transportadores serotoninérgicos en el proceso de la recuperación funcional cerebral del ictus isquémico experimental mediante técnicas de neuroimagen multimodal FUNDING

Departamento de educación, universidades e investigación, dirección de

política científica, proyectos de investigación (Gobierno Vasco) FROM

March 2011

MAIN RESEARCHER

TO

February 2014

Abraham Martín

PROJECT TITLE SaveMe: A Modular Active Nano-Platform for Advanced Cancer Management: Core nanosystems, tumor targeting and penetration, Molecular Imaging and Degradome based Therapy FUNDING

European Union (FP7/NMP-2010-4.0-1)

FROM

March 2011

MAIN REASEARCHER

TO

February 2015

Jordi Llop (subproject PI)

PROJECT TITLE Nanomedicina (nanoestructuras modulares biofuncionales para el diagnóstico y terapia de patologías cardiovasculares y cáncer utilizando técnicas de

imagen molecular) y puesta en marcha de mecanismos para la explotación de capacidades (ICTS – Unidad de Imagen Molecular) y resultados del centro FUNDING

Gobierno Vasco

FROM

Enero 2011

MAIN REASEARCHER

TO

Enero 2014

Jordi Llop (project coordinator and subproject PI)

PROJECT TITLE QNano:

A

pan-European

infrasctructure

for

quality

in

nanomaterials safety testing FUNDING

European Union

FROM

January 2010 TO

MAIN RESEARCHER

January 2014

ND

PROJECT TITLE AMIT: Advanced Molecular Imaging Tecnologies FUNDING

Ministerio de Ciencia e Innovación

FROM

June 2010

LEADER COMPANY

TO

December 2013

SEDECAL

PROJECT TITLE RADIOBORON: Síntesis de radiotrazadores PET con aplicación en BNCT FUNDING

Ministerio de Economía y Competitividad

FROM

August 2009 TO

MAIN RESEARCHER

August 2012

Jordi Llop Roig

PROJECT TITLE HINAMOX: Health Impact of Engineered Metal and Metal Oxide Nanoparticles: Response, Bioimaging and Distribution at Cellular and Body Level FUNDING

European Union

FROM

October 2009 TO

MAIN RESEARCHER

October 2012

Sergio Moya

PROJECT TITLE Investigación Estratégica y Desarrollo Tecnológico en imagen molecular, análisis multimodal y materiales híbridos FUNDING

Gobierno Vasco

FROM

January 2008 TO

MAIN RESEARCHER

January 2011

Jordi Llop (Project coordinator and PI of 2 subprojects)

PROJECT TITLE PHECOMP: Phenotypical Characterisation of Animal Models for Neuropsychiatric Disorders Related to Compulsive Behaviour FUNDING

European Union

FROM

January 2007 TO

MAIN RESEARCHER

December 2009

Olga Millán Portillo (Sub-project PI)

PROJECT TITLE DOPAGEN: Detección del Dopaje Genético por Factores de Crecimiento en un Modelo Animal (2). (Sub-project of a Coordinate Project with the same name) FUNDING

Ministerio de Educación y Ciencia (MEC)

FROM

January 2007 TO

MAIN RESEARCHER

December 2009

David Andreu Martínez (Sub-project PI)

PROJECT TITLE Neuroimagen Molecular en el Temblor Esencial: Estudio PET Multi-Trazador FUNDING

Instituto de Salud Carlos III – Ministerio de Sanidad (FIS)

FROM

January 2006 TO

MAIN RESEARCHER

December 2007

Alejandro Gironell

PROJECT TITLE Imagen Médica Molecular y Multimodal FUNDING

Instituto de Salud Carlos III – Ministerio de Sanidad (FIS)

FROM

January 2006 TO

MAIN RESEARCHER

December 2006

Juan Domingo Gispert

PRIVATE FOUNDATION PROJECT TITLE Determinación el efecto de la dieta en el proceso de envejecimiento en roedores: determinación del volumen de hipocampo y metabolismo glicídico en cerebro mediante Imagen por Resonancia Magnética y Tomografía por Emisión de Positrones. FUNDING

Abbott Nutritional

FROM

November 2011

MAIN RESEARCHER

TO

August 2012

Jordi Llop

PROJECT TITLE Cría y mantenimiento de ratas con dos dietas y evaluación de sus efectos cognitivos FUNDING

Abbott Nutritional

FROM

October 2011 TO

MAIN RESEARCHER

April 2012

Jordi Llop

PROJECT TITLE Medidas del volumen del cerebro e hipocampo mediante resonancia magnética de imagen en ratas FUNDING

Abbott Nutritional

FROM

August 2011 TO

MAIN RESEARCHER

September 2011

Jordi Llop

PROJECT TITLE Evolución de 2 formulaciones subcutáneas formantes de “DEPOT” mediante Imagen por Resonancia Magnética Nuclear en rata FUNDING

CRC CIM

FROM

October 2010 TO

MAIN RESEARCHER

March 2011

Jordi Llop

PROJECT TITLE IMAGENE. Non Invasive Molecular Imaging of Gene Expression Useful for Doping Control: Pilot Study in Animals after Erythropoietin Gene Transfer FUNDING

WADA (World Anti-Doping Agency)

FROM

January 2005 TO

MAIN RESEARCHER

December 2006

Jordi Segura

PROJECT TITLE Development

and

Implementation

of

the

Synthesis

and

Purification of Known 11C Radioligands for Neurotransmission PET Imaging FUNDING

GlaxoSmithKline (GSK)

FROM

June 2004

MAIN RESEARCHER

TO

May 2005

Jordi Llop Roig

PROJECT TITLE Development of Iodination Syntheses Procedures for Preparation of 123I-Labelled SPECT Ligands FUNDING

GlaxoSmithKline (GSK)

FROM

June 2004

MAIN RESEARCHER

TO

May 2005

Jordi Llop Roig

PROJECT TITLE Estudio Abierto para Caracterizar la Unión in-vivo a los Receptores 5HT2A del Radioligando

123

I-R91150 y su Desplazamiento por Ketanserina

en Voluntarios Sanos. FUNDING

GlaxoSmithKline (GSK)

FROM

February 2004

MAIN RESEARCHER

TO

July 2004

Ana M. Catafau

PROJECT TITLE Evaluación de SPECT Cerebral con 123I-ADAM para la Imagen y Cuantificación de Transportadores de Serotonina en Humanos FUNDING

Fundació la Marató de TV3

FROM

May 2003

MAIN RESEARCHER

TO

December 2004

Ana M. Catafau

STAYS IN OTHER CENTERS CENTER

National Institute of radiological Sciences (NIRS). Chiba, Japan

FROM

October 2008 TO

SUBJECT

Development of new radiotracers labelled with nitrogen-13 using

December 2008 13

N-

-

NO2 as a radioactive precursor. CENTER

Centro Nacional de Aceleradores (CNA). Sevilla, Spain

FROM

October 2007 TO

SUBJECT

Development and implementation of the synthesis and purification of

December 2007

known 18F radioligands.

CENTER

Uppsala Research Imaging Solutions AB. Uppsala, Sweden

FROM

September 2002

SUBJECT

Synthesis of labelled compounds with carbon-11 from carbon monoxide

TO

May 2003

using the Suzuki coupling reaction.

CENTER

Clínica Universitaria de Navarra. Pamplona, Spain

FROM

March 2002

SUBJECT

Synthesis of labelled compounds with carbon-11 from carbon monoxide

TO

September 2002

using the Suzuki coupling reaction.

OTHER MERITS - Reviewer of some International Journals such us ACS Nano, European Journal of Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters and Journal of Labelled Compounds and Radiopharmaceuticals. - Advisor of BIG (Barcelona Imaging Group S.L.). Barcelona, Spain (From March 2012 to Now). - Member of Sociedad Española Medicina Nuclear e Imagen Molecular (SEMNIM) (From March 2012 to now). - Member of scientific committee of CIC biomaGUNE. San Sebastián, Spain (From October 2011 to now). - Scientific Advisor of ICNAS – Produção Unipessoal. Coimbra, Portugal (From August 2010 to now). - Scientific Advisor of FGUMA PET center. Málaga, Spain (From January 2010 to December 2011). - Radioprotection Officer of the Radioactive Facility at CIC biomaGUNE (From October 2007 to December 2011). - Member of the scientific committee of the Singular Scientific-Technique Facility (in Spanish, ICTS) of the Molecular Imaging Platform at CIC biomaGUNE (From November 2006 to now). - Advisor to create the Molecular Imaging Unit at CIC biomaGUNE (From November 2006 to August 2007).

INVITED LECTURES 2012 •

Assessment of the biodistribution pattern and inflammatory response after acute administration of metal oxide Nps using Positron Emission Tomography. Safety Issues and Regulatory Challenges of Nanomaterials. San Sebastián, Spain. May, 2012.

•

Nitrogen-13: History, new synthetic strategies and future challenges. Radiochemistry Meeting Malmoe 2012. Malmoe, Sweden. March, 2012.

2011 •

Synthesis of Radiolabeled NPs for Biodistribution Studies in Animal Models. Safety issues of Nanomaterials along their life cycle Symposium. Barcelona, Spain. May, 2011.

•

PET

chemistry:

from

general

perspective

to

particular

applications.

Radiochemistry Workshop. Coimbra, Portugal. November, 2011. •

The other imaging technologies: complements for a multimodal approach? Workshop in Tissue Imaging. La Coruña, Spain. November, 2011.

2010 •

Nuevos trazadores sobre las enfermedades por depósito de proteínas del Sistema Nervioso central: aplicaciones clínicas y para la investigación. Neurociencia y biotecnología aplicadas: una mirada hacia las terapias neuroregeneradoras. San Sebastián, Spain. July, 2010.

2006 •

Ciclotrón: Síntesis de Radiofármacos. European Seminar on NeuroImaging and addiction. Barcelona, Spain. July, 2006.