PEMF RESEARCH The use of Pulsed Electromagnetic Fields (PEMF) for w e l l n e s s d a te s b a c k to t h e 1 9 t h c e n t u r y, a n d t h e s c i e n t i f i c studies regarding the benefits and applications of PEMF a r e e x te n s i ve , to s ay t h e l e a s t . W h i l e t h i s c o m p i l a t i o n i s m e r e l y a s u b s e t o f t h e e x te n s i ve r e s e a r c h r e g a r d i n g P E M F, i t i s a g r e a t s t a r t i n g p o i n t f o r l e a r n i n g m o r e a b o u t t h e s c i e n c e t h a t b a c k s t h i s i n c r e d i b l e te c h n o l o g y. T h i s d o c u m e n t w i l l t a ke yo u o n a j o u r n ey t h r o u g h e a r l y r e s e a r c h a r o u n d w hy a n d h o w P E M F w o r k s a n d f u r t h e r i n to the general wellness benefits that PEM F has been shown to p r ov i d e - b o t h f o r p e o p l e a n d a n i m a l s .

2

TABLE OF CONTENTS E A R LY D I S COV E R I E S A N D P U B L I C A T I O N S .. . . . . . . . . . . . . . . . . . . . . . . . . 4 C E L L S

A R E

L I K E

B AT T E R I E S.. . . . . . . . . . . . . . 5

H OW P E M F WO R K S : T H E M E C H A N I S M O F A M P L I F I E D

A C T I O N.. . . . . . . . . . . . . . 6

P E R FO R M A N C E

................ 7

AT H L E T E

T E S T I M O N I A L ..................... 8

N AT U R A L

R E C O V E R Y.. . . . . . . . . . . . . . . . . . . . . . . . 8

P U L S E P R O F E S S I O N A L T E S T I M O N I A L................................. 9 R E L A X AT I O N .................................. 9 E N H A N C E D

E N E R G Y.. . . . . . . . . . . . . . . . . . . . . . . 1 0

B E N E F I T S O F P E M F FO R H U M A N S................................. 1 1 V E T E R I N A RY

A P P L I C AT I O N S.............

1 2

H E A L I N G.. . . . . . . . . . . . . . . . . . . . . . . .

1 2

T E S T I M O N I A L.. . . . . . . . . . . . . . . . . . . .

1 3

N AT U R A L A N I M A L J O I N T

&

C A R T I L AG E

F U N C T I O N.. . . . . . . .

1 3

B E N E F I T S O F P E M F FO R A N I M A L S...............................

1 5

The information presented in this brochure is for your information only and is not a substitute for professional health advice . All P ulse products are meant for general wellness and have not been evaluated by the FDA . If you are experiencing symptoms of a physical or medical condition , you should seek the advice of a licensed medical professional immediately. 3

EARLY DISCOVERIES AND PUBLICATIONS H a r o l d S a x to n B u r r, P r o f e s s o r o f A n a to my a t Ya l e U n i ve r s i t y, s t u d i e d t h e p r e d i c t i ve e l e c t r o m a g n e t i c f i e l d s p r o d u c e d by the bodies of humans and animals and detailed his findings in publications such a s T h e F i e l d s o f L i f e , T h e E l e c t r i c P a t te r n s o f L i f e , a n d B l u e p r i n t f o r I m m o r t a l i t y.

In 20 01 , Professor James L . Oschman c o m p i l e d t h e e x te n s i ve r e s e a r c h - b a s e d ev i d e n c e a r o u n d e n e r g y a s a d r i ve r of normal health and wellbeing . His book Energy Medicine: The Scientific B a s i s m a ke s t h e c a s e f o r e n e r g y - b a s e d modalities as fundamental components of health & wellness regimens .

I n 2 0 1 0 , w o r l d - r e n o w n e d p hy s i c i a n , i n te r n a t i o n a l a u t h o r, a n d i n te g r a t i ve h e a l t h p r a c t i t i o n e r J e r r y Te n n a n t , M D released the first edition of his book H e a l i n g i s Vo l t a g e i n w h i c h h e e x p l o r e d t h e r e l a t i o n s h i p b e t w e e n vo l t a g e a c r o s s cell membranes and wellness .

“W it h e n o u gh v oltag e an d raw m ater ials, the body c a n h e a l a lm o s t a nyth in g . ” - Dr. J e rry Te nnant

4

CELLS ARE LIKE BATTERIES B I O E L E C T R I C A L U N D E R S TA N D I N G E N G I N E E R I N G O F C E L L B I O LO GY

A N D

(Journal of the Royal Societ y, 2020)

R e s e a rc h e r s f ro m th e U n i ve r s it y of Wa r w i c k ’s B i o - E l e c tr i c a l E n g i n e e r i n g I n n ova ti o n H u b ex p l a i n e d th a t a b i o e l e c tr i c a l v i ew of th e c e l l c o u l d e n h a n ce o u r a b i l it y to p re d i c t a n d co n tro l c e l l u l a r b e h av i o r. I n b o th e l e c tro c h e m i c a l ce l l s ( b a t te r i e s) a n d b i o l o g i c a l ce l l s , th e p a r titi o n i n g o f charged molecules and ions a c ro s s m e m b r a n e s i n a n d a ro u n d th e c e l l g i ve s r i s e to c h e m i c a l re a c ti o n s a n d i o n m ove m e n t s . We k n ow th a t w h e n b a t te r i e s a re l ow o n c h a r g e , th ey p e r f o r m s h o r t of th e i r p o te n ti a l . S i m i l a r l y, b i o l o g i c a l c e l l s th a t a re l ow o n c h a r g e w i l l a l s o ex h i b it d ys f u n c ti o n . M u c h

l i ke re c h a r g e a b l e b a t te r i e s f o r ce l l p h o n e s , l a pto p s , a n d c a r s , b i o l o g i c a l ce l l s c a n a l s o b e re c h a r g e d to f u n c ti o n o pti m a l l y. We c a n a l s o ex p e c t th a t j u s t a s s o m e re c h a r g e a b l e b a t te r i e s h o l d th e i r c h a r g e s l e s s a s th ey a g e , th e d u r a ti o n o r i m p a c t of re c h a r g i n g b i o l o g i c a l c e l l s w i l l va r y f ro m o n e ce l l / i n d i v i d u a l to th e n ex t . “The bioelectrical conceptualization of c e l l b e h av i o u r c a n b e illustrated with an analogy b e t we e n a b i o l o g i c a l c e l l a n d a b a t t e r y, b o t h o f w h i c h u s e r e d ox r e a c t i o n s a n d i o n m ove m e n t s .” 5

HOW PEMF WORKS: THE MECHANISM OF ACTION AM B I E NT AN D S U P P LE M E NTAL MAG N E TIC FIELDS PROMOTE MYOGENESIS VIA A TRPC1-MITOCHONDRIAL AXIS: EVIDENCE OF A MAGNETIC MITOHORMETIC MECHANISM ( The FAS EB Journal, 201 9) Af ter understanding that biologic al cells behave like e l e c t r o c h e m i c a l c e l l s ( b a t t e r i e s) t h r o u g h c h e m i c a l r e a c t i o n s a n d ion movement s , it helps to understand exac tly what cellular and sub - cellular reac tions and ion movement s take place under the i n f l u e n c e o f P E M F. W h i l e t h e r e f e r e n c e d a r t i c l e d i s c u s s e s P E M F ’s m e c h a n i s m o f a c t i o n o n m u s c l e c e l l s , t h e c o m p o n e n t s i n vo l v e d could translate to many other cells . For example, the TR P C 1 p r o t e i n i n vo l v e d i n t h i s s t u d y i s a vo l t a g e - g a t e d i o n c h a n n e l located on the plasma membrane of numerous human and animal c e l l t y p e s . P E M F h e l p s p o s i t i o n /o r i e n t T R P C 1 s o t h a t i t b e t t e r f a c i l i t a t e s t h e m o v e m e n t o f c a l c i u m (C a 2 +) i o n s i n t o t h e c e l l . Inside the cell, calcium ions... 1 . G e t t o t h e m i t o c h o n d r i a , w h i c h i n turn respires more 2 . A i d i n p r o d u c t i o n o f a n o t h e r p r o t e i n (c a l c i n e u r i n) w h i c h suppor ts the immune system , and 3 . S t i m u l a t e e p i g e n e t i c c a s c a d e s that suppor t production of mitochondria . In esse nce , with ( 1) and (3 ) you have more mitochondria available and each is respiring more , th e re by ge n e rating more ATP and e n e rgy for th e cell to do it s job. G ive n that TR P C 1 and oth e r voltage - gate d c alcium chann els are in so many dif fe re nt cells , it makes se nse that regardless of th e cells in q uestion , th e ce ntral impac t of PEM F is moving c alcium ions a nd stimulating mitochon drial respiration a n d re pro d uc tion , leading to greate r e n e rgy.

6

AMPLIFIED PERFORMANCE PE M F - ITS CO R R E L ATIO N TO E N HAN CE D E NE RGY, E NDU R ANCE , AND PE RFORMANCE . (Old D ominion Universit y, Frank Reidy Research Center for B ioelectrics , 201 9) I n 2 01 9 , O D U ’s C e nte r fo r B i o e l e c tri c s s tu d i e d th e ef fe c t s of P u l s e P E M F te c h n o l o g y o n rat s u b j e c t s a n d s u b s e q u e ntly m e a s u re d th e s u b j e c t s ’ b l o o d f l ow. T h e ave ra g e i n c re a s e i n b l o o d f l ow af te r e a c h P E M F s e s si o n wa s a b o u t 2 0 % g re ate r th a n th e b l o o d f l ow of th e co ntro l s u b j e c t s wh i c h we re n ot g ive n P E M F s e s si o n s . Ad d iti o n a lly,

b l o o d f l ow af te r 6 0 m i n u te s of P E M F tre atm e nt wa s sig n if i c a ntly h ig h e r th a n b l o o d f l ow af te r o n ly 1 5 m i n u te s of tre atm e nt . T h e re s e a rc h e r s co n cl u d e d th at th e re s u lt s p rovi d e evi d e n ce th at P E M Fs i m p rove b l o o d f l ow, e n h a n ce ox yg e n co n s u m pti o n , a n d b o o s t AT P p ro d u c ti o n by f a c ilit ati n g e l e c tro n tra n s p o r t . B y d o i n g s o , th ey m ay a l s o i n c re a s e s ke l et a l m u s cl e ce ll u l a r e n e rg y p ote nti a l . “PEMFs increase heat-independent blood-flow to skeletal m u s c l e a f t e r t r e a t m e n t . I n c r e a s e d b l o o d f l o w, l i k e t h a t d u r i n g exercise, enhances nutrient deliver y and facilitates gas e x c h a n g e i n a c t i v e o r i n j u r e d t i s s u e s .” This study was per formed on Pulse PEM F technology!

7

ATHLETE TESTIMONIAL CHRISTIAN GERING, U LT R A M A R AT H O N R U N N E R “This machine—the PEMF—really helps m e w i t h r e c ove r y, h e l p s w i t h b o d y aw a r e n e s s , a n d h e l p s w i t h t h e ove r a l l p r o g r e s s i o n t ow a r d , yo u k n ow, my s p o r t . I f i t i s a c o m p e t i t i ve e d g e , i t ’s a r e a l l y g o o d o n e . I t h i n k I ’m o n t o s o m e t h i n g and really I think there could be great benefits for athletes within the trail r u n n i n g wo r l d .” “At t he 50 mile mark, I knew I was well ahead of t he nex t competitor and ac tually ended up beating t hat competitor by 45 minutes in my first debut 100K . The course record still holds—it ’s 9:48 .”

NATURAL RECOVERY EFFECTS OF PULSED ELECTROMAGNETIC FIELD THERAPY ON D EL AYED-O NSE T MUSC LE SO REN ESS IN BI C EP S BR AC H I I . (P hysical Therapy in Spor t, 2015) The of ficial journal of the Association of Char tered Physiotherapists in Spor ts and Exercise Medicine published a study on PEM F’s impact on delayed-onset muscle soreness (DOMS) in biceps brachii on 30 healthy human subjects . Their objective was to compare the ef fects of PEM F with placebo treatment on variables in elbow flexors following an exercise regimen that would induce muscle soreness . “Overall, t he application of t he PEMF was found to be effec tive in reducing t he physiological deficits as sociated wit h DOMS [delayed onset muscle sorenes s], including improved recover y of perceived muscle sorenes s , increased median frequency (MDF), and enhanced elec tromechanical delay (EMD) during isometric contrac tion.”

8

PULSE PROFESSIONAL TESTIMONIAL SUSIE CAHILL, DRESSAGE RIDER Melbourne Pulse Therapy - Victoria, Au “A f t e r I f o u n d t h e P u l s e , I d i d n ’ t w a n t t o s t o p p u l s i n g . T h e m o d a l i t y o f P E M F, I was just so thrilled with it that I [r e n t e d ] t h i s m a t , a n d I t o o k i t w i t h me. I virtually had to sleep on it . . . a n d i t g o t m e t h r o u g h my t w o w e e k s o f r i d i n g . M y h u s b a n d w a s n ’ t c o n v i n c e d t h a t i t w a s d o i n g a ny t h i n g b e c a u s e i t ’ s a v e r y intangible feeling . . . but when he first experienced the Pulse P E M F m a c h i n e , h e s a i d , ‘ T h i s i s t h e o n e y o u ’ v e g o t t a g e t .”

RELAXATION COMPARISON OF THE EFFECTS OF MANUAL ACUPUNCTURE , L ASER ACUPUN C T URE , AND ELEC TRO MAG NE TI C FIELD S TIMUL ATI O N AT A C U P U N C T U R E P O I N T B L15 O N H E A R T R AT E V A R I A B I L I T Y . (Journal of Acupuncture and Meridian Studies , 2016) In this study, researchers focused on measuring heart rate variability (HRV), a key physiological metric for well-being. “An optimal level of HRV within an organism reflects healthy function and an inherent self-regulatory capacity, adaptability, and resilience.” They found that PEMF stimulation was identical to that of manual acupuncture in increasing HRV and activated the parasympathetic nervous system, typically responsible for rest and digestion. “In conclusion, we found that manual acupuncture and electromagnetic field stimulation [2 Hz and 460 gauss] at BL15 caused identical patterns for the activation of the parasympathetic nervous system.”

9

ENHANCED ENERGY EFFECTS OF A PULSED ELECTROMAGNE TIC THER APY ON MULTIPLE SCLEROSIS FATI G UE AND Q UALIT Y O F LIFE: A D O UBLE-BLIND, PLACEBO CONTROLLED TRIAL. (Alternative Therapies in Health and Medicine , 20 03 ) In this study, scientists from Washington , Virginia , and New Jersey conducted experiments on ef fects of PEM F on subjects with multiple sclerosis . In this multi-site, double -blind, placebo -controlled trial, researchers noticed improvements in fatigue and overall quality of life in subjects who were placed on the active PEM F device. While the researchers were adamant that their study should be replicated and expanded upon , they noted the human body as being highly responsive to PEM F therapy. “Specifically, subjec ts experienced significantly les s fatigue during t he four weeks t hey wore t he ac tive [PEMF] device t han t hey did while wearing t he placebo device.”

10

BENEFITS OF PEMF FOR HUMANS AS PEMF S TIMUL ATES AND E XERCISES THE CELL , IT IS AS IF THE CELL “WAKES UP” AND S TART S D O IN G WHAT IT NEEDS TO DO. IT GETS MOVING. IT GETS EXERCISED. THIS I S W H Y P E M F I S O F T E N R E F E R R E D T O A S “ C E L L U L A R E X E R C I S E ,” AND TH IS PRO CESS HAS SE VER AL IM PLI CATI O NS FO R HUMAN WELLNESS: O P T I M I Z E W E L L N E S S - N O N - I N VA S I V E LY

[1]

PEM F generates energy at the cellular level without medically invasive procedures . This amplification of natural energy encourages the body to function more ef fectively for overall wellness .

ENHANCE THE BODY’S NATU R AL R ECOVE RY PROCE SS

[2]

PEM F capitalizes on the body ’s intelligence and incredible self-healing capabilities , encouraging the cells with natural energy to better per form their many functions .

A SSIST WITH M USCLE FATIG U E & D I S C O M F O R T A F T E R E X E R C I S E [3] Complement any training program .

S U PP O RT G E N E R AL R E L A X ATIO N

[4, 5]

PEM F is a soothing and restorative modality.

E X P E R I E N C E M O R E E N E R G Y, N AT U R A L LY

[6, 7]

The body’s holistic nature uses PEMF as a catalyst for full-body energy.

AM PLI F Y ATH LE TIC PE R FO R MAN CE

[7, 8]

Harness the power of natural energy to supplement training and per formance goals . To locate the citations referenced here , visit info . pulsepemf.com/research [ 1 , 2 , 3 , 4 , 5 , 6 ,7, 8]

1 1

VETERINARY APPLICATIONS VE TERINARY APPLI CATI O NS O F PULSED ELEC TRO MAG NE TI C FIELD THERAPY (Research in Veterinar y Science , 201 8) Currently, this is the most comprehensive secondar y research study that exists on PEM F and its potential applications to animal wellness . This study explores the acceleration of PEM F in the veterinar y industr y in the last 1 0 years and why the modality is increasingly prescribed in the wellness regimens for animals of all sizes . “The data reviewed underscore t he usefulnes s of PEMF treatment as a safe, non -invasive treatment modality t hat has t he potential to become an impor tant stand -alone or adjunc tive treatment modality in veterinar y care.”

NATURAL HEALING EFFECTS OF PULSED ELECTROMAGNETIC FIELDS (PEMF) ON MOUSE BONE MARROW-DERIVED MACROPHAGES (Old D ominion Universit y, Frank Reidy Research Center for B ioelectrics , 201 9) In 2019, ODU ’s Center for Bioelectrics studied the ef fects of Pulse PEM F technology on mouse bone marrow- derived macrophages (specialized cells involved in the detection , phagocy tosis and destruction of bacteria and other harmful organisms). A number of results were obser ved including the upregulation of anti-inflammator y cy tokines (intercellular signalling molecules involved in immunity, inflammation and hematopoiesis), downregulation of inflammator y cy tokines , and enhancement of macrophages . “PEMF effec ts on macrophages* can enhance t he body ’s curative mechanisms to pos sibly clear infec tions and tis sue damage, dis sipate inflammation, and promote healing.” This study was per formed on Pulse PEM F technology!

12

ANIMAL TESTIMONIAL BRENDA TOBIN, W E L L N E S S M AT T E R S “My c lie nt ’s 3 ye a r old dog ’s sym pt om s we r e t hat s he u r i nat e d fr e q ue nt ly a nd had t o we a r d ia pe r s at n ig ht . S he wou ld vom it af t e r d r i n k i ng , had a d u ll co at , it c he d a nd had ve r y low e ne r gy. Af t e r t he fi r st se s s ion of P E M F, t he owne r r e por t e d he r dog had muc h mor e e ne r gy a nd s he d id not pe e t hat n ig ht . Af t e r t he t hi r d se s s ion , t he owne r wa s so i m p r e s se d wit h t he way he r dog fe lt t hat s he booke d s ix mor e se s s ion s . At t he e nd of t he s ix se s s ion s , he r dog wa s a ble t o t a ke wal k s a nd s he eve n we nt swi m m i ng ! The owne r s we r e so i m p r e s se d wit h t he pos it ive r e s u lt s t hey had se e n wit h PU L SE P E M F t hat t hey boug ht a mac hi ne for t he i r dog a n d t he i r fa mily! ”

JOINT & CARTILAGE FUNCTION EFFEC T S O F PULSED ELEC TRO MAG NE TI C FIELD THER APY AT D IFFERENT FREQ UEN CIES AND D UR ATI O NS O N ROTATO R CUFF T EN D O N-T O-B O N E H E ALI N G I N A R AT M O D EL . (Journal of Shoulder and Elbow Surger y, 201 8) In this study, 210 rat subjects underwent acute bilateral supraspinatus injury and repair followed by pulsed electromagnetic field stimulation for 1, 3, or 6 hours daily. Astoundingly, regardless of frequency or duration, improvements were seen in different mechanical properties on virtually all subjects that were given PEMF therapy. “Based on the results of this study, we speculate that PEMF treatment may increase tendon cell metabolism, which in turn increases both collagen production and matrix remodeling.”

1 3

COUPLING OF PULSED ELECTROMAGNETIC FIELDS (PEMF) THERAPY TO MOLECULAR GROUNDS OF THE CELL (American Journal of Translational Research , 201 8) T h i s co m p re h e n sive s c i e ntif i c revi ew s e r ve d 4 g o a l s: a) i nve s tig ate wh eth e r th e re we re tr u ly p o sitive cli n i c a l o u tco m e s af te r P E M F th e ra py ; b) s c re e n exp e ri m e nt a l s tu d i e s d e a li n g with P E M F a n d m u s c u l o s ke l et a l ce ll s a n d ti s s u e , e s p e c i a lly re g a rd i n g i nte rl e u k i n s a n d T N F- a c) s e a rc h fo r a n e l e c tro m a g n eti c i ntri n si c co u nte r p a r t a n d trig g e r fo r P E M F i n ce ll s a n d ti s s u e s a n d d) l o o k fo r c a u s a l m o l e c u l a r a n d ce ll u l a r m e c h a n i s m s of p o s si b l e P E M F a c ti o n s . A m o n g th e s e re s u lt s:

“[PEMF] is beneficial for bot h pas sive physical movement and for physical training per formed by t he patient .” “PEMF can lead to chondroprotec tive effec ts on joint car tilage in animal models .” “Proliferation, differentiation and synt hesis of car tilage matrix proteins are enhanced by PEMF.”

14

BENEFITS OF PEMF FOR ANIMALS OPTIMIZE ANIMAL WELLNESS N O N - I N V A S I V E LY [1] PEM F generates energy at the cellular level without invasive procedures . This amplification of natural energy encourages the body to function more ef fectively for overall wellness .

INCREASE RANGE OF MOTION

[7, 8]

Decreased inflammation and increased circulation may suppor t the extension of muscle fibers .

G E N E R ATE NATU R AL CE LLU L AR E N E RGY

[6, 7]

The holistic nature of an animal ’s body uses PEM F as a catalyst for full-body energy.

N AT U R A L S U P P O R T FO R H E A LTH Y J O I NT & C A R T I L A G E F U N C T I O N [9, 10] Studies show that PEM F has the potential to improve calcium and collagen production .

A SSIST WITH M USCLE FATIG U E & D I S C O M F O R T A F T E R E X E R C I S E [3] Reinforce any training program to help keep athletes fit and minimize stall rest.

S U PP O RT G E N E R AL R E L A X ATIO N

[4, 5]

PEM F is a relaxing and restorative modality that provides sedationfree, gentle pulsing.

CO M P LE M E NTARY M O DALIT Y

[11]

Use in conjunction with other wellness modalities and complement veterinar y-led treatment plans . To locate the citations referenced here , visit info . pulsepemf.com/research [ 1 , 3 , 4 , 5 , 6 ,7, 8 , 9 , 1 0 , 1 1 ]

1 5

34 Center Rd SE • Atlanta, GA 30121 • T: 888.952.7030 • www.pulsepemf.com

PCV-BRC-001-04292021WF-001