Clinical Research Coordinator, Neurology. Hospital Clinico San Carlos, Madrid, (Spain) Head of Multiple Sclerosis Unit, Neurology

Curriculum Vitae PERSONAL INFORMATION Celia Oreja-Guevara WORK EXPERIENCE May 2012 – Present Clinical Research Coordinator, Neurology Hospital Cli

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Curriculum Vitae

PERSONAL INFORMATION

Celia Oreja-Guevara

WORK EXPERIENCE May 2012 – Present

Clinical Research Coordinator, Neurology Hospital Clinico San Carlos, Madrid, (Spain)

December 2006 – May 2012

Head of Multiple Sclerosis Unit, Neurology Hospital Universitario La Paz, Madrid, (Spain)

January 2004 – November 2006

Coordinator of the Neurology Department Hospital de Fuenlabrada, Neurology, (Spain)

2003 – 2003

Senior Neurologist / Research Fellow Department of Neurology, University of Duesseldorf (Germany) and Neurobiology, Bochum, (Germany)

2002 – 2002

Senior Neurologist in Neuroimaging Department of Neurology, University Hospital San Raffaele, Milan , (Italy)

2001 – 2001

Senior Neurologist / Research Fellow Department of Neurology, University of Duesseldorf (Germany) and Neurobiology, Bochum, (Germany)

1997 – 2001

Senior Neurologist Department of Neurology, University of Bochum, (Germany)

1992 – 1997

Resident in Neurology University Hospital Bergmannsheil, Augustahospital Isselburg, (Germany)

October 1990 – March 1992

Research Fellow in Neuroimmunology, Resident in Neurology Department of Neuroimmunology, Max-Planck-Institut für Neurobiologie, Munich-Martinsried, (Germany)

EDUCATION AND TRAINING September 1984 – July 1990

Medical Doctor Medical School, University Complutense of Madrid, (Spain)

© European Union, 2002-2013 | http://europass.cedefop.europa.eu

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Curriculum Vitae

October 1990 – March 1992

Celia Oreja-Guevara

PhD University of Ludwig-Maximilian and Max-Planck Institut für Neurobiologie, Munich, (Germany) Thesis: Interaction of T lymphocytes with cerebral endothelial cells in EAE

1994 – 1994

General Medicine (GP), Madrid (Spain)

1992 – 1997

Specialist of Neurology (Germany)

1997 – 2000

Bachelor Clinical examinations of laboratory in neurology University Hospital Bergmannsheil , Bochum, (Germany)

2004 – 2005

Master Management of Integrated Health Systems (Executive Education) ESADE University, Madrid, (Spain)

2010 – 2011

MS Master in Neuroimmunology Autónoma University of Barcelona, (Spain)

ADDITIONAL INFORMATION Expertise

Research areas Clinical and neuroimaging correlations in multiple sclerosis. Non-conventional Techniques of Magnetic Resonance in multiple sclerosis Utility of optical coherence tomography in MS Changes in cytokines and regulatory cells in different MS treatments Principal Investigator in many MS clinical trials

Publications

Oreja-Guevara C, Montalban X, de Andres C, Casanova-Estruch B, Munoz-Garcia D, Garcia I, Fernandez O. [Consensus document on spasticity in patients with multiple sclerosis]. Rev Neurol. 2013 Oct 16;57(8):359-73. Noval S, Oreja-Guevara C, Contreras I. Monitoring neuromyelitis optica activity. Expert Rev Neurother. 2013 Sep;13(9):989-99. Brück W, Gold R, Lund BT, Oreja-Guevara C, Prat A, Spencer CM, Steinman L, Tintoré M, Vollmer TL, Weber MS, Weiner LP, Ziemssen T, Zamvil SS. Therapeutic Decisions in Multiple Sclerosis: Moving Beyond Efficacy. JAMA Neurol. 2013 Aug 5. Oreja-Guevara C, Wiendl H, Kieseier BC, Airas L . Specific aspects of modern life for people with multiple sclerosis: considerations for the practitioner. Ther Adv Neurol Disord. Epub August 27, 2013. García-Merino A, Fernández O, Montalbán X, de Andrés C, Oreja-Guevara C, Rodríguez-Antigüedad A, Arbizu T. Consensus Statement on medication use in multiple sclerosis by the Spanish Society of Neurology's study group for demyelinating diseases. Neurologia. 2013 Jul-Aug;28(6):375-8 Kalincik T, Vivek V, Jokubaitis V, Lechner-Scott J, Trojano M, Izquierdo G,

© European Union, 2002-2013 | http://europass.cedefop.europa.eu

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Curriculum Vitae

Celia Oreja-Guevara

Lugaresi A, Grand'maison F, Hupperts R, Oreja-Guevara C, et al. on behalf of the MSBase Study Group. Sex as a determinant of relapse incidence and progressive course of multiple sclerosis. Brain. 2013 Oct 18. Hughes SE, Spelman T, Gray OM, Boz C, Trojano M, Lugaresi A, Izquierdo G, Duquette P, Girard M, Grand'maison F, Grammond P, Oreja-Guevara C, Hupperts R, Et al. for the MSBase study group. Predictors and dynamics of postpartum relapses in women with multiple sclerosis. Mult Scler. 2013 Oct 9 Fernandez O, Arnal-Garcia C, Arroyo-Gonzalez R, Brieva L, Calles-Hernandez MC, Casanova-Estruch B, Comabella M, de Las Heras V, Garcia-Merino JA, Hernandez-Perez MA, Izquierdo G, Matas E, Meca-Lallana JE, Mendibe-Bilbao MM, Munoz-Garcia D, Olascoaga J, Oreja-Guevara C, Prieto JM et al. Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (III). Rev Neurol. 2013 Oct 1;57(7):317-329. Fernandez O, Arnal-Garcia C, Arroyo-Gonzalez R, Brieva L, Calles-Hernandez MC, Casanova-Estruch B, Comabella M, de Las Heras V, Garcia-Merino JA, Hernandez-Perez MA, Izquierdo G, Matas E, Meca-Lallana JE, Mendibe-Bilbao MM, Munoz-Garcia D, Olascoaga J, Oreja-Guevara C, et al. Grupo Post-Ectrims GP. Review of the novelties presented at the 28th Congress of the uropean Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) II). Rev Neurol. 2013 Sep 16;57(6):269-81. Fernández Ó, Arnal-García C, Arroyo-González R, Brieva L, Calles-Hernández MC, Casanova-Estruch B, Comabella M, de Las Heras V, García-Merino JA, Hernández-Pérez MA, Izquierdo G, Matas E, Meca-Lallana JE, Mendibe-Bilbao Mdel M, Muñoz-García D, Olascoaga J, Oreja-Guevara C et al. Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (I). Rev Neurol. 2013 Sep 1;57(5):217-29 Fernández Ó, Arroyo-González R, Rodríguez-Antigüedad A, García-Merino JA, Comabella M, Villar LM, Izquierdo G, Tintoré M, Oreja-Guevara C, Álvarez-Cermeño JC, Meca-Lallana JE, Prieto JM, Ramió-Torrentà L, Martínez-Yélamos S, Montalban X. Biomarkers in multiple sclerosis. Rev Neurol. 2013 Apr 1;56(7):375-90. Oreja-Guevara C, González-Segura D, Vila C. Spasticity in multiple sclerosis: results of a patient survey. Int J Neurosci. 2013 Jun;123(6):400-8 Iuliano G, Boz C, Cristiano E, Duquette P, Lugaresi A, Oreja-Guevara C, Van Pesch V. Historical changes of seasonal differences in the frequency of multiple sclerosis clinical attacks: a multicenter study. J Neurol. 2012 Dec 21. Trojano M, Lucchese G, Graziano G, Taylor BV, Simpson S Jr, Lepore V, Grand'maison F, Duquette P, Izquierdo G, Grammond P, Amato MP, Bergamaschi R, Giuliani G, Boz C, Hupperts R, Van Pesch V, Lechner-Scott J, Cristiano E, Fiol M, Oreja-Guevara C, Saladino ML, Verheul F, Slee M, Paolicelli D, Tortorella C, D'Onghia M, Iaffaldano P, Direnzo V, Butzkueven H; MSBase Study Group and the New Zealand MS Prevalence Study Group. Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis. PLoS One. 2012;7(10):e48078 Oreja-Guevara C. [Treatment of spasticity in multiple sclerosis: new perspectives regarding the use of cannabinoids]. Rev Neurol. 2012 Oct 1;55(7):421-30. Oreja-Guevara C, Ramos-Cejudo J, Stark Aroeira L, Chamorro B, Diez-Tejedor E. TH1/TH2 Cytokine profile in relapsing-remitting multiple sclerosis patients treated with Glatiramer acetate or Natalizumab. BMC Neurol. 2012 Sep 18;12(1):95. Carmen Arnal-Garcia , M.Rosa García-Montero , Ignacio Málaga ,Jorge Millán-Pascual , Pedro OlivaNacarino, Lluís Ramió-Torrentà, Celia Oreja-Guevara. Natalizumab use in pediatric patients with relapsing-remitting multiple sclerosis. Eur J Paed Neurol 2012 Sep 26. pii: S1090-3798(12)00196-1 Fox RJ, Miller DH, Phillips JT, Hutchinson M, Havrdova E, Kita M, Yang M,bRaghupathi K, Novas M, Sweetser MT, Viglietta V, Dawson KT; CONFIRM Study Investigators. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med. 2012 Sep 20;367(12):1087-97. Rieckmann P, Boyko A, Centonze D, Coles A, Elovaara I, Havrdova E, Hommes O, Lelorier J, Morrow SA, Oreja-Guevara C, Rijke N, Schippling S. Future MS care: a consensus statement of the MS in the 21st Century Steering Group. J Neurol. 2012 Aug 31 Meyniel C, Spelman T, Jokubaitis VG, Trojano M, Izquierdo G, Grand'maison F, Oreja-Guevara C,

© European Union, 2002-2013 | http://europass.cedefop.europa.eu

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Curriculum Vitae

Celia Oreja-Guevara

Boz C, Lugaresi A, Girard M, Grammond P, Iuliano G, Fiol M, Cabrera-Gomez JA, FernandezBolanos R, Giuliani G, Lechner-Scott J, Cristiano E, Herbert J, Petkovska-Boskova T, Bergamaschi R, van Pesch V, Moore F, Vella N, Slee M, Santiago V, Barnett M, Havrdova E, Young C, Sirbu CA, Tanner M, Rutherford M, Butzkueven H; on behalf of the MSBasis Study Group. Country, Sex, EDSS Change and Therapy Choice Independently Predict Treatment Discontinuation in Multiple Sclerosis and Clinically Isolated Syndrome. PLoS One. 2012;7(6):e38661 Fernandez O, Alvarez-Cermeno JC, Arroyo-Gonzalez R, Brieva L, Calles-HernandezMC, CasanovaEstruch B, Comabella M, de Las Heras V, Garcia-Merino JA,Hernandez-Perez MA, Izquierdo G, Meca-Lallana JE, Munoz-Garcia D, Olascoaga J,Oreja-Guevara C, Prieto JM, Ramio-Torrenta L, Rodriguez-Antiguedad A,Romero-Pinel L, Sanchez F, Tellez N, Tintore M, Montalban X, Grupo PostEctrims GP. Review of the novelties presented at the 27th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II). Rev Neurol. 2012 Jun 16;54(12):734749 Oreja-Guevara C. Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity. Expert Rev Neurother 2012; 12(4s), 3-8 Oreja-Guevara C, Noval S,Alvarez-Linera J, Gabaldón L, Manzano B, Chamorro, B, Diez-Tejedor E. Clinically isolated syndromes suggestive of multiple sclerosis: an optical coherence tomography study. PloS One 2012;7(3): e33907 Meca-Lallana JE, Balseiro JJ, Lacruz F, Guijarro C, Sanchez O, Cano A, Costa-Frossard L, Hernandez-Clares R, Sanchez-de la Rosa R; Escala Study Group. Spasticity improvement in patients with relapsing-remitting multiple sclerosis switching from interferon-ß to glatiramer acetate: the Escala Study. J Neurol Sci. 2012 Apr 15;315(1-2):123-8 Fernandez O, Alvarez-Cermeno JC, Arroyo-Gonzalez R, Brieva L, Calles-Hernandez MC, CasanovaEstruch B, Comabella M, de Las Heras V, Garcia-Merino JA, Hernandez-Perez MA, Izquierdo G, Meca-Lallana JE, Munoz-Garcia D, Olascoaga J, Oreja-Guevara C, Prieto JM, Ramio-Torrenta L, Rodriguez-Antiguedad A, Romero-Pinel L, Sanchez F, Tellez N, Tintore M, Montalban X, Grupo PostEctrims GP. Review of the novelties presented at the 27th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (I). Rev Neurol. 2012 Jun 1;54(11):677-691 Kister I, Chamot E, Cutter G, Bacon TE, Jokubaitis VG, Hughes SE, Gray OM, Trojano M, Izquierdo G, Grand'maison F, Duquette P, Lugaresi A, Grammond P, Boz C, Hupperts R, Petersen T, Giuliani G, Oreja-Guevara C, Iuliano G, Lechner-Scott J, Bergamaschi R, Rio ME, Verheul F, Fiol M, Van Pesch V, Slee M, Butzkueven H, Herbert J; with the MSBase Investigators. Increasing age at disability milestones among MS patients in the MSBase Registry. J Neurol Sci. 2012 Jul 15;318(1-2):94-9 Lugaresi A, Ziemssen T, Oreja-Guevara C, Thomas D, Verdun E. Improving patient-physician dialog:commentary on the results of the MS Choices survey. Patient Preference and Adherence 2012, 6:143-152 Fernández O, Oreja-Guevara C, Arroyo R, Izquierdo G, Pérez JL, Montalban X. Natalizumab treatment of multiple sclerosis in Spain: results of an extensive observational study. J Neurol. 2012 Jan 31 Hughes S, Spelman T, Trojano M, Lugaresi A, Izquierdo G, Grand'maison F, Duquette P, Girard M, Grammond P, Oreja-Guevara C, Hupperts R, Boz C, Bergamaschi R, Giuliani G, Rio ME, LechnerScott J, van Pesch V, Iuliano G, Fiol M, Verheul F, Barnett M, Slee M, Herbert J, Kister I, Vella N, Moore F, Petkovska-Boskova T, Shaygannejad V, Jokubaitis V, McDonnell G, Hawkins S, Kee F, Gray O, Butzkueven H; on behalf of the MSBase Study Group. The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results from the MSBase Registry. J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):305-310. Lechner-Scott J, Spencer B, de Malmanche T, Attia J, Fitzgerald M, Trojano M, Grand'maison F, Antonio C Gomez J, Izquierdo G, Duquette P, Girard M, Grammond P, Oreja-Guevara C, Hupperts R, Bergamaschi R, Boz C, Giuliani G, Pesch VV, Iuliano G, Fiol M, Cristiano E, Verheul F,Saladino ML, Slee M, Barnett M, Deri N,Fletcher S, Vella N, Shaw C, Herbert J, Moore F, Petkovska-Boskova T, Jokubatis V, Butzkueven H. The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude. Mult Scler.2012 Jul;18(7):974-82. Fernández O, García-Merino JA, Arroyo R, Alvarez-Cermeño JC, Arbizu T, Izquierdo G, Saiz A, J Olascoaga, Rodríguez-Antigüedad A, Prieto JM, Oreja-Guevara C, Hernández MA, Montalbán X. Spanish consensus on the use of natalizumab (Tysabri(®)) Neurología 2012 Sep;27(7):432-441 Noval S, Contreras I, Muñoz S, Oreja-Guevara C, Manzano B, Rebolleda G. Optical coherence tomography in multiple sclerosis and neuromyelitis optica: an update. Mult Scler Int. 2011;2011:472790.

© European Union, 2002-2013 | http://europass.cedefop.europa.eu

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Curriculum Vitae

Celia Oreja-Guevara

Abraira V, Alvarez-Cermeño JC, Arroyo R, Cámara C, Casanova B, Cubillo S, de Andrés C, Espejo C, Fernández O, Ferrer J, Figueredo MA, García-Merino A, García-Sánchez MI, García-Trujillo JA, Gómez M, González-Oria C, Gosis A, Izquierdo G, Jímenez J, López-Trascasa M, Montalbán X, Moreno MJ, Muñoz D, Nuñez V, Muriel A, Navarro J, Olascoaga J, Oreja-Guevara C, Prada A, Ramil E, Ramo-Tello C, Rodríguez C, Rodríguez E, Rodríguez-Frías F, Rodríguez-Antigüedad A, Rodríguez-Molina JJ, Ruiz E, Saiz A, Sarasola E, Simó M, Yagüe J, Villar LM. Utility of oligoclonal IgG band detection for MS diagnosis in daily clinical practice. J Immunol Methods. 2011 Aug 31;371(12):170-3 Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice Joao Carlos Correia de Sa, Laura Airas, Emmanuel Bartholome, Nikolaos Grigoriadis, Heinrich Mattle, Celia Oreja-Guevara, Jonathan O'Riordan, Finn Sellebjerg, Bruno Stankoff, Karl Vass, Agata Walczak, Heinz Wiendl, and Bernd C. Kieseier Ther Adv Neurol Disord.2011;4 139-168 Ramos-Cejudo J., Oreja-Guevara C, Luiz Stark Aroeira L, Rodriguez de Antonio L, Chamorro B, DiezTejedor E. Treatment with Natalizumab in Relapsing-Remitting Multiple Sclerosis patients induces changes in inflammatory mechanism. J Clin Immunol. 2011 Aug;31(4):623-31 Rodríguez de Rivera FJ, Oreja Guevara C, Sanz Gallego I, San José Valiente B, Santiago Recuerda A, Gómez Mendieta MA, Arpa J, Díez Tejedor E. Outcome of patients with amyotrophic lateral sclerosis attending a multidisciplinary care unit. Neurologia. 2011 Oct;26(8):455-60. Fernandez-Fernandez O, Alvarez-Cermeno JC, Arbizu-Urdiain T, Arroyo-Gonzalez R, Arnal-Garcia C, Casanova-Estruch B, Calles-Hernandez MC, Coret-Ferrer F, Comabella M, Garcia-Merino JA, de Las Heras V, Izquierdo G, Meca-Lallana JE, Munoz-Garcia D, Olascoaga J, Oreja-Guevara C, Prieto JM, Rodriguez-Antiguedad A, Tintore M, Montalban X, Grupo Post-Ectrims GP. [Review of the novelties presented at the 26th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II).]. Rev Neurol. 2011 Mar 1;52(5):289-299 Fernandez-Fernandez O, Alvarez-Cermeno JC, Arbizu-Urdiain T, Arroyo-Gonzalez R, Arnal-Garcia C, Casanova-Estruch B, Calles-Hernandez MC, Coret-Ferrer F, Comabella-Lopez M, Garcia-Merino JA, de Las Heras V, Izquierdo G, Meca-Lallana JE, Munoz-Garcia D, Olascoaga J, Oreja-Guevara C, Prieto JM, Rodriguez-Antiguedad A, Tintore M, Montalban X, Grupo Post-Ectrims GP. [Review of the novelties presented at the 26th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (I).]. Rev Neurol. 2011 Feb 16;52(4):227-238. Merino JJ, Montes ML, Blanco A, Bustos MJ, Oreja-Guevara C, Bayon C, Cuadrado A, Lubrini G, Cambron I, Munoz A, Cebolla S, Gutierrez-Fernandez M, BernardinobJI, Arribas JR, Fiala M. [HIV-1 neuropathogenesis: therapeutic strategies against neuronal loss induced by gp120/Tat glycoprotein in the central nervous system.]. Rev Neurol. 2011 Jan 16;52(2):101-111. Benito-León J, Rivera-Navarro J, Guerrero AL, de Las Heras V, Balseiro J, Rodríguez E, Belló M, Martínez-Martín P; caregiver quality of life in multiple sclerosis (CAREQOL-MS) Study Group. The CAREQOL-MS was a useful instrument to measure caregiver quality of life in multiple sclerosis. J Clin Epidemiol. 2011 Jun;64(6):675-86. Jaime Ramos-Cejudo , Celia Oreja-Guevara . El papel de las células Th-17 en la Esclerosis Múltiple. Revista Española de Esclerosis Múltiple 2010, 14, 5-8 Oreja-Guevara C, Miralles A, García-Caballero J, Noval S, Gabaldón L, Esteban-Vasallo MD, GarcíaMatres MJ, Bayón-Pérez C, Royo A, González A, Hernanz A, López-Pajares MR, Morante JL, Díez-Tejedor E. Clinical pathways for the care of multiple sclerosis patients. Neurologia. 2010 Apr;25(3):156-162 Oreja-Guevara C, Noval S, Manzano B, Gabaldón L, Diez-Tejedor E. Optic neuritis, multiple sclerosis-related or not: structural and functional study. Neurología, 2010:25(2):78-82 Gabaldón Torres L , Aguilar-Amat Prior MJ , Oreja-Guevara C, Diez-Tejedor E Retinopathy and renal failure in a patient with multiple sclerosis under treatment with beta-interferon. Medicina Clínica 2010 Apr 17;134(11):511 Bermejo PE, Oreja-Guevara C, Diez-Tejedor E. [Pain in multiple sclerosis: prevalence, mechanisms, types and treatment.]. Rev Neurol. 2010 Jan 16-31;50(2):101-8 C. Oreja-Guevara, P. E. Bermejo, A. Miralles, L. Gabaldón, M. J. Aguilar, E. Díez-Tejedor. Acetato de glatiramero en pacientes con esclerosis múltiple remitente-recurrente no respondedores al interferón beta . Neurología 2009;24(7):435-438 Oreja-Guevara C. Neuromarketing. Neurología Supl 2009;5(1):4-7 Rivera-Navarro J, Benito-León J, Oreja-Guevara C, Pardo J, Bowakim Dib W, Orts E, Belló M. Burden and health-related quality of life of Spanish caregivers of persons with multiple sclerosis. Mult Scler.

© European Union, 2002-2013 | http://europass.cedefop.europa.eu

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Curriculum Vitae

Celia Oreja-Guevara

2009 Nov;15(11):1347-55 Oreja-Guevara C, Lubrini G. Deterioro cognitivo en esclerosis múltiple. Revista Española de Esclerosis Múltiple 2009, 12, 9-16 Peña P, Sancho J, Rufo M, Martínez S, Rejas J; LINCE Study Collaborative Group. Driving cost factors in adult outpatients with refractory epilepsy: a daily clinical practice in clinics of neurology in Spain. Epilepsy Res. 2009Feb;83(2-3):133-43. Rufo-Campos M, Sancho-Rieger J, Peña P, Masramon X, Rejas-Gutiérrez J; Grupo de Colaboradores del Estudio LINCE. [Drug regimens in patients with medication-resistant epilepsy in neurology and epilepsy outpatient departments in Spain]. Rev Neurol. 2008 Nov 16-30;47(10):517-24. Celia Oreja-Guevara, Susana Noval. La tomografía de coherencia óptica en la neuritis óptica y en la esclerosis múltiple. Revista Española de Esclerosis Múltiple 2008, 6, 22-26. Sancho J, Peña P, Rufo M, Palacios G, Masramon X, Rejas J; LINCE Study Collaborative Group. Health and non-health care resources use in the management of adult outpatients with drug-resistant epilepsy in Spain: a cost-of-illness study (LINCE study). Epilepsy Res. 2008 Oct;81(2-3):176-87. Oreja-Guevara C . Nuevas Técnicas de Resonancia en Esclerosis Múltiple. Timely topics in Medicine, Neurologia (http://ww2.ttmed.com/esclerosis_múltiple) Diciembre 2007 (Técnicas de diagnóstico ).Prous Science C. Oreja-Guevara, D. Caputo, M. P. Sormani, M. Filippi. Alteraciones de la sustancia gris en pacientes con esclerosis múltiple remitente-recurrente. Revista Española de Esclerosis Múltiple 2006, 1, 5-11. C. Oreja-Guevara, A. Charyl, D. Caputo, R. Cavarretta, M. P. Sormani, M. Filippi. Magnetization transfer magnetic resonance imaging and clinical changes in patients with relapsing-remitting multiple sclerosis. Archives of Neurology 2006 May; 63(5):736-40. C. Oreja-Guevara, M. Rovaris, G. Iannucci, P. Valvasina, D. Caputo, R. Cavarretta, M. P. Sormani, P. Ferrante, G. Comi, M. Filippi. Progressive grey matter damage in patients with relapsing-remitting MS: A longitudinal difussion tensor MRI study . Archives of Neurology, 2005 Apr;62(4):578-84. C. Oreja Guevara, R.Kleiser, W. Paulus, Kruse W. R.J. Seitz, K.-P. Hoffmann The role of V5 (hMT+) in visually guided hand movements: an fMRI study. Eur J Neurosci. 2004 Jun;19(11):3113-20. W. Kruse, C. Oreja-Guevara, K.-P. Hoffmann. Sehen und Bewegen: ein Feuerwerk der Nervenzellen. Neurorubin 2003, 27- 30. J. Liepert, C. Oreja-Guevara, L.G. Cohen, M. Tegenthoff, M. Hallet, J.-P. Malin. Plasticity of cortical hand muscle representation in patients with hemifacial spasm. Neurosci. Lett. 1999 Sep 3;272(1):3336. C. Oreja-Guevara, E. Sindern, M. Raulf-Heimsoth, J.-P. Malin. Analysis of lymphocyte subpopulations in cerebrospinal fluid and peripheral blood in patients with multiple sclerosis and inflammatory diseases of the nervous system. Acta Neurol Scand. 1998 Nov; 98(5): 310-313. E. Sindern, C. Oreja-Guevara, M. Raulf-Heimsoth, J.-P. Malin. A longitudinal study of circulating lymphocyte subsets in the peripheral blood during the acute stage of Guillain-Barre syndrome. J Neurol Sci. 1997 Oct 3;151(1):29-34. C. Oreja Guevara, E. Sindern, M. Raulf-Heimsoth, J.-P. Malin. Analysis of lymphocyte subpopulations in cerebrospinal fluid and peripheral blood by flow cytometry of patients with multiple sclerosis. Aktuelle Neurologie, Band 23(1996): S80. E. Sindern, LM Ossege, C. Oreja, A. Kirov, J.-P. Malin. Klinische Bedeutung hoher Anti-GM1Antikörper bei Patienten mit akutem Guillain-Barré-Syndrom. Aktuelle Neurologie 1995: 22: 136-139. E. Sindern, LM Ossege, C. Oreja, J.-P Malin. Klinische Wertigkeit von hohen anti-GM1-Antikörpern bei akut entzündlichen Radikulopathien. Verhandlungen der Deutschen Gesellschaft für Neurologie 8 (1994) 510-11. Books Esclerosis múltiple. C. Oreja-Guevara. En: Neurología. Una introducción a la especialidad Editorial: Eisai. Madrid, 2012.Pag. 47-58 ISBN: 978-84-92987-19-1 Terapia actual de pacientes con esclerosis múltiple. C. Oreja-Guevara. En: Tysem: Tratamiento y Seguridad de Esclerosis múltiple en 360°. Editorial: Let´s health, Madrid, 2011.Pag. 63-79 ISBN: 97884-614-6791-4 Leucoencefalopatía multifocal progresiva. Otros efectos adversos asociados a natalizumab. J. Berenguer Berenguer , C. Oreja-Guevara, J. Meca Lallana. En: Tysem: Tratamiento y Seguridad de Esclerosis múltiple en 360°. Editorial: Let´s health. Madrid, 2011 Pag. 181-225 ISBN: 978-84-614-

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Curriculum Vitae

Celia Oreja-Guevara

6791-4 Enfermedades desmielinizantes. Oscar Fernández, Celia Oreja-Guevara et al. Investigación de enfermedades neurológicas en España. Documento de consenso sobre estrategias y prioridades. Editor: Sociedad Española de Neurología, 2010. Pág. 61-70. ISBN 978-84-7989-641-6 Biomarcadores. M. Comabella, C. Oreja Guevara. En : Esclerosis Múltiple. Editorial Marge. Barcelona, 2010. Pag. 361-373 ISBN: 978-84-92442-93-5 Episodios desmielinizantes de etiología desconocida. Oreja Guevara C. En: Casos exepcionales en Neurología. Editor: Vivancos Matellano F. Madrid, 2009. Pág. 80-86. ISBN 978-84-7989-562-4 Projects

Neurogenesis in progressive forms of Multiple sclerosis (FIS 020107) 2013-2014 Efficacy of pschychotherapeutic treatment of mindfulness in patients with Multiple Sclerosis Ayuda Fundación Salud 2000 de Investigación en Enfermedades Neurodegenerativas. 2013-2014. Magnetic Resonance Imaging (MRI) and Optical Coherence Tomography (OCT) study in RRMS patients treated with Fingolimod. Third Party. 2013-2016 Study of cytoquines and regulatory cells in patients with Multiple Sclerosis . 2008-2012 FUTURA SEN guideline study by Spanish neurologists in the treatment of patients with multiple sclerosis. 2010-2012 Diffusion tensor study in patients with ALS. Hospital Ruber Internacional 2007-2011 Serial assessment of relapsing-remitting Multiple Sclerosis patients with magnetisation transfer and acute neurological syndromes using difussion tensor magnetic resonance imaging MRI”. Hospital Universitario de “San Raffaele” en Milán (Italia), European Neurological Society. 2002-2003 “Plasticity of Spatial Cognition” , Stiftung Volkswagen, University Hospital Bergmannsheil and University Hospital Düsseldorf ( Germany) 2001-2004

Memberships

Chairman of the demyelinating diseases group of the Spanish Society of Neurology (2009-2012) Chairman of the demyelinating diseases group of the Society of Neurology of Madrid (2005-present) Chairman of the neuroimaging group of the Spanish Society of Neurology (2013-present) Board Member of the Society of Neurology of Madrid (2004-2010) Board Member of the educational advisory comittee of the Spanish Neurological Society (2005-2008) Board Member of the research Group of Multiple Sclerosis of the University of Bochum, Germany (1995-2001) Member of the Scientist Panel on Multiple Sclerosis and other Demyelinating Diseases of EFNS (2010-present) Member of ECTRIMS Comittee (2011-present) Member of the spanish network of multiple sclerosis (REEM) (2009-present)

Other Relevant Information

Scientific Awards European Federation of Neurological Societies (EFNS) – Award for the best free presentation (short comunications, posters) in Multiple Sclerosis (2012) Neurological Society of Madrid – Award for the best oral comunication (2011) Spanish Neurological Society -Award for the best publication (2010) Neurological Society of Madrid – Award for the best poster (2009) Neurological Society of Madrid – Award for the best oral comunication (2008) Spanish Neurological Society -Award for the best publication (2006) “Neurólogos para el futuro”- Award (Spanish Neurological Society, 2004) JOURNALS Editorial Board Member of Neurologia (journal of Spanish Neurological Society) (2005-2008) Editorial Board Member of Esclerosis Múltiple (spanish journal of MS) ( 2004- present) Editorial Board Member of Neuroinmunología (spanish journal of Neuroimmunology) ( 2010- present)

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Curriculum Vitae

Celia Oreja-Guevara

Journal Editor Academic Editor of Plos One Journal Reviewer Plos One Neurology Journal of Neuroinflammation Therapeutic Advances in Neurological Disorders Journal of Immunological Methods Expert Review of Pharmacoeconomics& Outcomes Research Neurology International JNNP Revista de Neurología Neurología

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